TUG 891

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Description: Potent and selective FFA4 (GPR120) agonist
Chemical Name: 4-[(4-Fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]-benzenepropanoic acid
Purity: ≥99% (HPLC)
Citations (3)

Biological Activity for TUG 891

TUG 891 is a potent FFA4 (GPR120) agonist (pEC50 values are 7.36 and 7.77 for human and mouse GPR120 respectively). Selective for GPR120 over free fatty acid receptors (pEC50 = 4.19 for FFA1; displays no activity at FFA2 or FFA3). Cell permeable.

Licensing Information

Sold under license from the University of Southern Denmark.

Compound Libraries for TUG 891

TUG 891 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for TUG 891

M. Wt 364.41
Formula C23H21FO3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 1374516-07-0
PubChem ID 57522038
Smiles FC1=CC(COC2=CC=C(CCC(O)=O)C=C2)=C(C3=CC=C(C)C=C3)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TUG 891

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 36.44 100

Preparing Stock Solutions for TUG 891

The following data is based on the product molecular weight 364.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.74 mL 13.72 mL 27.44 mL
5 mM 0.55 mL 2.74 mL 5.49 mL
10 mM 0.27 mL 1.37 mL 2.74 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

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Product Datasheets for TUG 891

Certificate of Analysis / Product Datasheet
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References for TUG 891

References are publications that support the biological activity of the product.

Shimpukade et al (2012) Discovery of a potent and selective GPR120 agonist. J.Med.Chem. 55 4511 PMID: 22519963

If you know of a relevant reference for TUG 891, please let us know.

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Keywords: TUG 891, TUG 891 supplier, TUG891, GPR120, agonists, potent, selective, FFA1, FFA2, FFA3, cell, permeable, FFA4, free, fatty, acid, receptors, Free, Fatty, Acid, Receptors, 4601, Tocris Bioscience

3 Citations for TUG 891

Citations are publications that use Tocris products. Selected citations for TUG 891 include:

Maillard et al (2018) Docosahexaenoic acid (DHA) effects on proliferation and steroidogenesis of bovine granulosa cells. Reprod Biol Endocrinol 16 40 PMID: 29699561

Jeremy F et al (2019) Omega-3 Fatty Acids Activate Ciliary FFAR4 to Control Adipogenesis. Cell 179 1289-1305.e21 PMID: 31761534

J Silvio et al (2019) Illuminating G-Protein-Coupling Selectivity of GPCRs. Cell 177 1933-1947.e25 PMID: 31160049

Do you know of a great paper that uses TUG 891 from Tocris? Please let us know.

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