TUG 891

Pricing Availability Delivery Time Qty
Cat.No. 4601 - TUG 891 | C23H21FO3 | CAS No. 1374516-07-0
Description: Potent and selective FFA4 (GPR120) agonist
Chemical Name: 4-[(4-Fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]-benzenepropanoic acid
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent FFA4 (GPR120) agonist (pEC50 values are 7.36 and 7.77 for human and mouse GPR120 respectively). Selective for GPR120 over free fatty acid receptors (pEC50 = 4.19 for FFA1; displays no activity at FFA2 or FFA3). Cell permeable.

Licensing Information

Sold under license from the University of Southern Denmark.

Compound Libraries

TUG 891 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 364.41
Formula C23H21FO3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 1374516-07-0
PubChem ID 57522038
InChI Key LPGBXHWIQNZEJB-UHFFFAOYSA-N
Smiles FC1=CC(COC2=CC=C(CCC(O)=O)C=C2)=C(C3=CC=C(C)C=C3)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.44 100

Preparing Stock Solutions

The following data is based on the product molecular weight 364.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.74 mL 13.72 mL 27.44 mL
5 mM 0.55 mL 2.74 mL 5.49 mL
10 mM 0.27 mL 1.37 mL 2.74 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

Shimpukade et al (2012) Discovery of a potent and selective GPR120 agonist. J.Med.Chem. 55 4511 PMID: 22519963


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Keywords: TUG 891, supplier, TUG891, GPR120, agonists, potent, selective, FFA1, FFA2, FFA3, cell, permeable, FFA4, free, fatty, acid, receptors, Free, Fatty, Acid, Receptors, Free, Fatty, Acid, Receptors, Tocris Bioscience

Citations for TUG 891

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GPCR

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