Tubastatin A hydrochloride

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Cat.No. 6270 - Tubastatin A hydrochloride | C20H21N3O2.HCl | CAS No. 1310693-92-5
Description: Potent HDAC6 inhibitor
Chemical Name: N-Hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]benzamide hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent HDAC6 inhibitor (IC50 = 0.015 μM). Exhibits some selectively for HDAC6 over HDAC8 and 1 (IC50 values are 0.854 and 16.4 μM, respectively). Induces elevated levels of α-tubulin and protects against glutathione-induced oxidative stress in primary neuronal cell culture. Reverses the axonal loss in peripheral neurons in mouse model of Charcot-Marie-Tooth disease.

Technical Data

M. Wt 371.86
Formula C20H21N3O2.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1310693-92-5
PubChem ID 57336514
InChI Key LJTSJTWIMOGKRJ-UHFFFAOYSA-N
Smiles CN1CCC2=C(C3=CC=CC=C3N2CC4=CC=C(C(NO)=O)C=C4)C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 3.72 10 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 371.86. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.69 mL 13.45 mL 26.89 mL
5 mM 0.54 mL 2.69 mL 5.38 mL
10 mM 0.27 mL 1.34 mL 2.69 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Butler et al (2010) Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A J.Am.Chem.Soc. 132 10842

d'Ydewalle et al (2011) HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1-induced Charcot-Marie-Tooth disease. Nature medicine 7 26 PMID: 21785432


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Citations for Tubastatin A hydrochloride

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