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Cat.No. 3402 - Tubacin | C41H43N3O7S | CAS No. 1350555-93-9
Description: HDAC6 inhibitor; inhibits α-tubulin deacetylation
Chemical Name: N-[4-[(2R,4R,6S)-4-[[(4,5-Diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N'-hydroxyoctanediamide
Purity: ≥98% (HPLC)

Biological Activity

Selective inhibitor of HDAC6; inhibits the second deacetylase domain (DD2). Does not inhibit HDAC6 histone deacetylase activity; reversibly inhibits α-tubulin deacetylation. Increases α-tubulin acetylation levels with no effect on histone acetylation or cell cycle progression.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of Tubacin is reviewed on the Chemical Probes website.

Technical Data

M. Wt 721.86
Formula C41H43N3O7S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1350555-93-9
PubChem ID 6675804
Smiles OCC(C=C4)=CC=[C@@]4[C@@H]1C[C@H](CSC2=NC(C6=CC=CC=C6)=C(C5=CC=CC=C5)O2)O[C@H]([C@]3=CC=C(NC(CCCCCCC(NO)=O)=O)C=C3)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 7.22 10

Preparing Stock Solutions

The following data is based on the product molecular weight 721.86. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.39 mL 6.93 mL 13.85 mL
5 mM 0.28 mL 1.39 mL 2.77 mL
10 mM 0.14 mL 0.69 mL 1.39 mL
50 mM 0.03 mL 0.14 mL 0.28 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Haggarty et al (2003) Multidimensional chemical genetic analysis of diversity-orientated synthesis-derived deacetylase inhibitors using cell-based assays. Chem.Biol. 10 383 PMID: 12770821

Haggarty et al (2003) Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation. Proc.Natl.Acad.Sci.USA 100 4389 PMID: 12677000

Jiang et al (2008) Direct binding with histone deacetylase 6 mediates the reversible recruitment of parkin to the centrosome. J.Neurosci. 28 12993 PMID: 19036992

If you know of a relevant reference for Tubacin, please let us know.

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Keywords: Tubacin, supplier, Tubacin, HDAC, inhibitors, class, II, histone, deacetylase, inhibits, deacetylases, alpha-tubulin, α-tubulin, a-tubulin, acetylation, HDAC6, epigenetics, [537049-40-4], Histone, Deacetylases, Histone, Deacetylases, Tocris Bioscience

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