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Description: Selective M4 antagonist
Chemical Name: N-Ethyl-3-hydroxy-2-phenyl-N-(pyridinylmethyl)propanamide
Purity: ≥98% (HPLC)
Biological Activity for Tropicamide
Tropicamide is an M4 selective muscarinic receptor antagonist.
Compound Libraries for Tropicamide
Tropicamide is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
Technical Data for Tropicamide
| M. Wt | 284.36 |
| Formula | C17H20N2O2 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 1508-75-4 |
| PubChem ID | 5593 |
| InChI Key | BGDKAVGWHJFAGW-UHFFFAOYSA-N |
| Smiles | CCN(CC1=CC=NC=C1)C(=O)C(CO)C1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Tropicamide
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 100 |
Preparing Stock Solutions for Tropicamide
The following data is based on the product molecular weight 284.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.52 mL | 17.58 mL | 35.17 mL |
| 5 mM | 0.7 mL | 3.52 mL | 7.03 mL |
| 10 mM | 0.35 mL | 1.76 mL | 3.52 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.7 mL |
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Product Datasheets for Tropicamide
References for Tropicamide
References are publications that support the biological activity of the product.
Hernandez et al (1993) Different muscarinic receptor subtypes mediating the phasic activity and basal tone of pig isolated intravesical ureter. Br.J.Pharmacol. 110 1413 PMID: 7905771
Lazareno et al (1990) Characterisation of muscarinic M4 binding sites in rabbit lung, chicken heart and NG 108-15 cells. Mol.Pharmacol. 38 805 PMID: 2250662
If you know of a relevant reference for Tropicamide, please let us know.
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Keywords: Tropicamide, Tropicamide supplier, Selective, M4, muscarinic, antagonists, Muscarinic, Receptors, Acetylcholine, ACh, 0909, Tocris Bioscience
1 Citation for Tropicamide
Citations are publications that use Tocris products. Selected citations for Tropicamide include:
Sallo et al (2012) The IS/OS junction layer in the natural history of type 2 idiopathic macular telangiectasia. Invest Ophthalmol Vis Sci 53 7889 PMID: 23092925
Do you know of a great paper that uses Tropicamide from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Alzheimer's Disease Poster
Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.
Learning & Memory Poster
Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.