Tropanyl-3,5-dimethylbenzoate

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Cat.No. 0641 - Tropanyl-3,5-dimethylbenzoate | C17H23NO2 | CAS No. 85181-40-4
Description: 5-HT3 antagonist
Purity: ≥99%
Datasheet
Citations (2)
Reviews
Literature (2)

Biological Activity

5-HT3 antagonist.

Technical Data

M. Wt 273.37
Formula C17H23NO2
Storage Store at RT
Purity ≥99%
CAS Number 85181-40-4
PubChem ID 2837530
InChI Key HDDNYFLPWFSBLN-UHFFFAOYSA-N
Smiles CN1C2CCC1CC(C2)OC(=O)C1=CC(C)=CC(C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 13.67 50

Preparing Stock Solutions

The following data is based on the product molecular weight 273.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 7.32 mL 36.58 mL 73.16 mL
2.5 mM 1.46 mL 7.32 mL 14.63 mL
5 mM 0.73 mL 3.66 mL 7.32 mL
25 mM 0.15 mL 0.73 mL 1.46 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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References

References are publications that support the biological activity of the product.

Fozard and Gitto (1983) Selective blockade of 5-hydroxytryptamine neuronal receptors by benzoic acid esters of tropine. Br.J.Pharmacol. 80 511P


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Keywords: Tropanyl-3,5-dimethylbenzoate, Tropanyl-3,5-dimethylbenzoate supplier, 5-HT3, antagonists, Serotonin, Receptors, 0641, Tocris Bioscience

2 Citations for Tropanyl-3,5-dimethylbenzoate

Citations are publications that use Tocris products. Selected citations for Tropanyl-3,5-dimethylbenzoate include:

Dolma et al (2016) Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells. Cancer Cell 29 859 PMID: 27300435

Yang et al (2010) Activation of submucosal 5-HT(3) receptors elicits a somatostatin-dependent inhibition of ion secretion in rat colon. Br J Pharmacol 159 1623 PMID: 20233224


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Ion Channel

Ion Channel Product Listing

A collection of around 500 products for ion channel research, the listing includes research tools for the study of:

  • Ligand-gated ion channels
  • Voltage-gated ion channels
  • Other Ion Channels
5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.