TRO 19622

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Cat.No. 2906 - TRO 19622 | C27H45NO | CAS No. 22033-87-0
Description: Binds voltage-dependent anion channel (VDAC)
Alternative Names: Olesoxime
Chemical Name: Cholest-4-en-3-one oxime
Purity: ≥98% (HPLC)
Citations (2)

Biological Activity

Neuroprotective and neuroregenerative compound. Rescues motor neurons from axotomy-induced cell death and promotes nerve regeneration following sciatic nerve crush in vivo. Binds directly to two components of the mitochondrial permeability pore, the voltage-dependent anion channel (VDAC) and translocator protein; thought to inhibit MPTP opening.

Technical Data

M. Wt 399.65
Formula C27H45NO
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 22033-87-0
PubChem ID 76971721
Smiles [H][C@@]23CCC1=CC(CC[C@@](C)1[C@]([H])2CC[C@@]4(C)[C@]([H])3CC[C@@]([H])4[C@@H](CCCC(C)C)C)=NO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 19.98 50
ethanol 7.99 20

Preparing Stock Solutions

The following data is based on the product molecular weight 399.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.5 mL 12.51 mL 25.02 mL
5 mM 0.5 mL 2.5 mL 5 mL
10 mM 0.25 mL 1.25 mL 2.5 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Bordet et al (2007) Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis. J.Pharmacol.Exp.Ther. 322 709 PMID: 17496168

If you know of a relevant reference for TRO 19622, please let us know.

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2 Citations for TRO 19622

Citations are publications that use Tocris products. Selected citations for TRO 19622 include:

González et al (2016) Blocking mitochondrial calcium release in Schwann cells prevents demyelinating neuropathies. Front Neurosci 126 1023 PMID: 26878172

Skals et al (2014) Bacterial RTX toxins allow acute ATP release from human erythrocytes directly through the toxin pore. J Biol Chem 289 19098 PMID: 24860098

Do you know of a great paper that uses TRO 19622 from Tocris? If so please let us know.

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