TRO 19622

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Cat.No. 2906 - TRO 19622 | C27H45NO | CAS No. 22033-87-0
Description: Binds voltage-dependent anion channel (VDAC)
Alternative Names: Olesoxime
Chemical Name: Cholest-4-en-3-one oxime
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Literature

Biological Activity

Neuroprotective and neuroregenerative compound. Rescues motor neurons from axotomy-induced cell death and promotes nerve regeneration following sciatic nerve crush in vivo. Binds directly to two components of the mitochondrial permeability pore, the voltage-dependent anion channel (VDAC) and translocator protein; thought to inhibit MPTP opening.

Technical Data

M. Wt 399.65
Formula C27H45NO
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 22033-87-0
PubChem ID 76971721
InChI Key QNTASHOAVRSLMD-GYKMGIIDSA-N
Smiles [H][C@@]23CCC1=CC(CC[C@@](C)1[C@]([H])2CC[C@@]4(C)[C@]([H])3CC[C@@]([H])4[C@@H](CCCC(C)C)C)=NO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 19.98 50
ethanol 7.99 20

Preparing Stock Solutions

The following data is based on the product molecular weight 399.65. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5 mL 25.02 mL 50.04 mL
2.5 mM 1 mL 5 mL 10.01 mL
5 mM 0.5 mL 2.5 mL 5 mL
25 mM 0.1 mL 0.5 mL 1 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Bordet et al (2007) Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis. J.Pharmacol.Exp.Ther. 322 709 PMID: 17496168


If you know of a relevant reference for TRO 19622, please let us know.

Keywords: TRO 19622, TRO 19622 supplier, Neuroprotective, neuroregenerative, Binds, voltage-dependent, anion, VDAC, Channels, modulators, Other, TRO19622, mitochondrial, pore, MPTP, olesoxime, spinal, muscular, atrophy, SMA, Olesoxime, Channel, Modulators, Miscellaneous, Compounds, 2906, Tocris Bioscience

2 Citations for TRO 19622

Citations are publications that use Tocris products. Selected citations for TRO 19622 include:

Skals et al (2014) Bacterial RTX toxins allow acute ATP release from human erythrocytes directly through the toxin pore. J Biol Chem 289 19098 PMID: 24860098

González et al (2016) Blocking mitochondrial calcium release in Schwann cells prevents demyelinating neuropathies. Front Neurosci 126 1023 PMID: 26878172


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Literature in this Area

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