Tris DBA

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Cat.No. 3416 - Tris DBA | C51H42O3Pd2 | CAS No. 51364-51-3
Description: N-myristoyltransferase-1 inhibitor; antiproliferative
Chemical Name: Tris(dibenzylideneacetone) dipalladium

Biological Activity

N-myristoyltransferase-1 (NMT-1) inhibitor that prevents activation of MAPK, PI 3-K and STAT3 signaling pathways. Exhibits antiproliferative activity against melanoma cells in vitro and in vivo. Also used as a cyclization catalyst.

Technical Data

M. Wt 915.73
Formula C51H42O3Pd2
Storage Store at RT
CAS Number 51364-51-3
PubChem ID 9811564
Smiles [Pd].[Pd].O=C(\C=C\C1=CC=CC=C1)/C=C/C1=CC=CC=C1.O=C(\C=C\C1=CC=CC=C1)/C=C/C1=CC=CC=C1.O=C(\C=C\C1=CC=CC=C1)/C=C/C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 10.07 11

Preparing Stock Solutions

The following data is based on the product molecular weight 915.73. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.11 mM 9.93 mL 49.64 mL 99.27 mL
0.55 mM 1.99 mL 9.93 mL 19.85 mL
1.1 mM 0.99 mL 4.96 mL 9.93 mL
5.5 mM 0.2 mL 0.99 mL 1.99 mL

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References are publications that support the biological activity of the product.

Bhandarkar et al (2008) Tris(Dibenzylideneacetone) dipalladium, a N-myristoyltransferase-1 inhibitor, is effective against melanoma growth in vitro and in vivo. Clin.Cancer Res. 14 5743 PMID: 18794083

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