TRIM

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Cat.No. 0919 - TRIM | C10H7F3N2 | CAS No. 25371-96-4
Description: nNOS/iNOS inhibitor
Chemical Name: 1-(2-Trifluoromethylphenyl)imidazole
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

A potent inhibitor of neuronal and inducible NO synthases, with much lower affinity for the endothelial isoform (displays IC50 values of 28.2, 27.0 and 1057.5 μM respectively). Antinociceptive in vivo.

Technical Data

M. Wt 212.17
Formula C10H7F3N2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 25371-96-4
PubChem ID 1359
InChI Key WZBWBNCQUTXYEL-UHFFFAOYSA-N
Smiles FC(F)(F)C1=C(C=CC=C1)N1C=CN=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 21.22 100
DMSO 10.61 50

Preparing Stock Solutions

The following data is based on the product molecular weight 212.17. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.71 mL 23.57 mL 47.13 mL
5 mM 0.94 mL 4.71 mL 9.43 mL
10 mM 0.47 mL 2.36 mL 4.71 mL
50 mM 0.09 mL 0.47 mL 0.94 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Handy et al (1995) The antinociceptive effect of 1-(2-trifluoromethylphenyl)imidazole (TRIM), a potent inhibitor of neuronal nitric oxide synthase in vitro, in the mouse. Br.J.Pharmacol. 116 2349 PMID: 8581267

Handy et al (1996) Inhibition of nitric oxide synthase by 1-(2-trifluoromethylphenyl)imidazole (TRIM) in vitro: antinociceptive and cardiovascular effects. Br.J.Pharmacol. 119 423 PMID: 8886430

Tooker et al (2013) Nitric oxide mediates activity-dependent plasticity of retinal bipolar cell output via S-nitrosylation. J.Neurosci. 33 19176 PMID: 24305814


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Keywords: TRIM, TRIM supplier, nNOS/iNOS, inhibitors, inhibits, Non-Selective, NOS, Nitric, Oxide, Signaling, Signalling, NO, Synthases, Non-selective, 0919, Tocris Bioscience

1 Citation for TRIM

Citations are publications that use Tocris products. Selected citations for TRIM include:

Zanardo et al (1997) Pharmacological and immunohistochemical evidence for a functional nitric oxide synthase system in rat peritoneal eosinophils. Proc Natl Acad Sci U S A 94 14111 PMID: 9391161


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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