TRIM

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Cat.No. 0919 - TRIM | C10H7F3N2 | CAS No. 25371-96-4
Description: nNOS/iNOS inhibitor
Chemical Name: 1-(2-Trifluoromethylphenyl)imidazole
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

A potent inhibitor of neuronal and inducible NO synthases, with much lower affinity for the endothelial isoform (displays IC50 values of 28.2, 27.0 and 1057.5 μM respectively). Antinociceptive in vivo.

Technical Data

M. Wt 212.17
Formula C10H7F3N2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 25371-96-4
PubChem ID 1359
InChI Key WZBWBNCQUTXYEL-UHFFFAOYSA-N
Smiles FC(F)(F)C1=C(C=CC=C1)N1C=CN=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.61 50
ethanol 21.22 100

Preparing Stock Solutions

The following data is based on the product molecular weight 212.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.71 mL 23.57 mL 47.13 mL
5 mM 0.94 mL 4.71 mL 9.43 mL
10 mM 0.47 mL 2.36 mL 4.71 mL
50 mM 0.09 mL 0.47 mL 0.94 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Handy et al (1995) The antinociceptive effect of 1-(2-trifluoromethylphenyl)imidazole (TRIM), a potent inhibitor of neuronal nitric oxide synthase in vitro, in the mouse. Br.J.Pharmacol. 116 2349 PMID: 8581267

Handy et al (1996) Inhibition of nitric oxide synthase by 1-(2-trifluoromethylphenyl)imidazole (TRIM) in vitro: antinociceptive and cardiovascular effects. Br.J.Pharmacol. 119 423 PMID: 8886430

Tooker et al (2013) Nitric oxide mediates activity-dependent plasticity of retinal bipolar cell output via S-nitrosylation. J.Neurosci. 33 19176 PMID: 24305814


If you know of a relevant reference for TRIM, please let us know.

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Keywords: nNOS/iNOS inhibitors inhibits Non-Selective NOS Nitric Oxide Signaling Signalling NO Synthases Non-selective NOS

1 Citation for TRIM

Citations are publications that use Tocris products. Selected citations for TRIM include:

Zanardo et al (1997) Pharmacological and immunohistochemical evidence for a functional nitric oxide synthase system in rat peritoneal eosinophils. Proc Natl Acad Sci U S A 94 14111 PMID: 9391161


Do you know of a great paper that uses TRIM from Tocris? If so please let us know.

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pathways for TRIM

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