TPPU

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Cat.No. 5918 - TPPU | C16H20F3N3O3 | CAS No. 1222780-33-7
Description: Potent soluble epoxide hydrolase inhibitor; orally bioavailable and brain penetrant
Chemical Name: N-[1-(1-Oxopropyl)-4-piperidinyl]-N'-[4-(trifluoromethoxy)phenyl]urea
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent soluble epoxide hydrolase (sEH) inhibitor (IC50 values are 1.1 and 2.1 nM for murine and human receptor, respectively). Inhibits MAPK and NF-κB signaling, as well as reducing ER stress and cell death in models of pancreatitis. Exhibits antidepressant effects in a social defeat stress model. Orally bioavailable and brain penetrant.

Technical Data

M. Wt 359.34
Formula C16H20F3N3O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1222780-33-7
PubChem ID 44142782
InChI Key AAJMQTLFRTZCJK-UHFFFAOYSA-N
Smiles CCC(N1CCC(NC(NC2=CC=C(C=C2)OC(F)(F)F)=O)CC1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 17.97 50
DMSO 35.93 100

Preparing Stock Solutions

The following data is based on the product molecular weight 359.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.78 mL 13.91 mL 27.83 mL
5 mM 0.56 mL 2.78 mL 5.57 mL
10 mM 0.28 mL 1.39 mL 2.78 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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References

References are publications that support the biological activity of the product.

Ren et al (2016) Gene deficiency and pharmacological inhibition of soluble epoxide hydrolase confers resilience to repeated social defeat stress. Proc.Natl.Acad.Sci.U.S.A. 113 E1944 PMID: 26976569

Bettaieb et al (2015) Soluble epoxide hydrolase pharmacological inhibition ameliorates experimental acute pancreatitis in mice. Mol.Pharmacol. 88 281 PMID: 25993999

Rose et al (2010) 1-Aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: structure-activity relationships, pharmacokinetics, and reduction of inflammatory pain. J.Med.Chem. 53 7067 PMID: 20812725


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