TPPU

Discontinued Product

TPPU (Cat. No. 5918) has been withdrawn from sale for commercial reasons.
Cat.No. 5918 - TPPU | C16H20F3N3O3 | CAS No. 1222780-33-7
Description: Potent soluble epoxide hydrolase inhibitor; orally bioavailable and brain penetrant
Chemical Name: N-[1-(1-Oxopropyl)-4-piperidinyl]-N'-[4-(trifluoromethoxy)phenyl]urea
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews

Biological Activity for TPPU

TPPU is a potent soluble epoxide hydrolase (sEH) inhibitor (IC50 values are 1.1 and 2.1 nM for murine and human receptor, respectively). Inhibits MAPK and NF-κB signaling, as well as reducing ER stress and cell death in models of pancreatitis. Exhibits antidepressant effects in a social defeat stress model. Orally bioavailable and brain penetrant.

Technical Data for TPPU

M. Wt 359.34
Formula C16H20F3N3O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1222780-33-7
PubChem ID 44142782
InChI Key AAJMQTLFRTZCJK-UHFFFAOYSA-N
Smiles CCC(N1CCC(NC(NC2=CC=C(C=C2)OC(F)(F)F)=O)CC1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for TPPU

References are publications that support the biological activity of the product.

Ren et al (2016) Gene deficiency and pharmacological inhibition of soluble epoxide hydrolase confers resilience to repeated social defeat stress. Proc.Natl.Acad.Sci.U.S.A. 113 E1944 PMID: 26976569

Bettaieb et al (2015) Soluble epoxide hydrolase pharmacological inhibition ameliorates experimental acute pancreatitis in mice. Mol.Pharmacol. 88 281 PMID: 25993999

Rose et al (2010) 1-Aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: structure-activity relationships, pharmacokinetics, and reduction of inflammatory pain. J.Med.Chem. 53 7067 PMID: 20812725

View Related Products by Target

View Related Products by Product Action

View all Other Hydrolase Inhibitors

Keywords: TPPU, TPPU supplier, potent, soluble, epoxide, hydrolase, inhibitors, inhibits, brain, penetrant, orally, bioavailable, antidepressant, anti-inflammatory, Other, Hydrolases, 5918, Tocris Bioscience

Citations for TPPU

Citations are publications that use Tocris products.

Currently there are no citations for TPPU.

Reviews for TPPU

There are currently no reviews for this product. Be the first to review TPPU and earn rewards!

Have you used TPPU?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review