TP 064

Pricing Availability   Qty
Cat.No. 6008 - TP 064 | C28H34N4O2 | CAS No. 2080306-20-1
Description: Potent and selective PRMT 4 inhibitor
Chemical Name: N-Methyl-N-((2-(1-(2-(methylamino)ethyl)piperidin-4-yl)pyridin-4-yl)methyl)-3-phenoxybenzamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and selective PRMT4 inhibitor; inhibits methylation of H3 (1-25) and MED12 (IC50 values are <10 and 43 nM, respectively). Exhibits >100-fold selectivity over other histone methyltransferases and non-epigenetic targets. Inhibits proliferation of certain multiple myeloma cell lines, arresting cells in G1 phase.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the TP 064 probe summary on the SGC website.

Technical Data

M. Wt 458.6
Formula C28H34N4O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2080306-20-1
PubChem ID 122707126
InChI Key VUIITYLFSAXKIQ-UHFFFAOYSA-N
Smiles O=C(N(C)CC1=CC(C2CCN(CCNC)CC2)=NC=C1)C3=CC=CC(OC4=CC=CC=C4)=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 45.86 100
DMSO 45.86 100

Preparing Stock Solutions

The following data is based on the product molecular weight 458.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.18 mL 10.9 mL 21.81 mL
5 mM 0.44 mL 2.18 mL 4.36 mL
10 mM 0.22 mL 1.09 mL 2.18 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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References

References are publications that support the biological activity of the product.

Nakayama et al (2018) TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma. Oncotarget 9 18480 PMID: 29719619


If you know of a relevant reference for TP 064, please let us know.

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Keywords: TP 064, TP 064 supplier, TP064, Potent, allosteric, inhibitors, inhibits, of, protein, arginine, methyltransferase, 4, PRMT4, methylation, Protein, Arginine, Methyltransferases, 6008, Tocris Bioscience

Citations for TP 064

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Literature in this Area

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