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Biological Activity for TP-040
TP-040 is a potent and selective O-GlcNAcase (OGA) inhibitor (IC50 = 46 nM). It increases the level of O-GlcNAcylated protein in human neuroblastoma SH-SY5Y cells (EC50 = 450 nM). It is suitable for in vivo studies and exhibits brain permeability.
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the TP-040 probe summary on the SGC website.
Technical Data for TP-040
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TP-040
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for TP-040
The following data is based on the product molecular weight 286.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.49 mL||17.46 mL||34.92 mL|
|5 mM||0.7 mL||3.49 mL||6.98 mL|
|10 mM||0.35 mL||1.75 mL||3.49 mL|
|50 mM||0.07 mL||0.35 mL||0.7 mL|
References for TP-040
References are publications that support the biological activity of the product.
Tawada et al (2021) Discovery of a novel and brain-penetrant O-GlcNAcase inhibitor via virtual screening, structure-based analysis, and rational lead optimization. J.Med.Chem. 64 1103 PMID: 33404239
If you know of a relevant reference for TP-040, please let us know.
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Citations for TP-040
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