Tocriscreen Kinase Inhibitor Toolbox I
A collection of 80 kinase inhibitors supplied pre-dissolved in DMSO (250 μL 10 mM solution). Comprises a subset of the Tocriscreen Plus (Cat. No. 5840) compound library. Contains compounds covering more than 40 different target kinases including VEGFR, AKT, CDKs, EGFR, p38 MAPK, Src Kinases and TGF-β receptors.
This replaces Tocriscreen Kinase Inhibitor Toolbox (Cat. No. 3514).
Key Format and Product Details
- 96-well rack with Matrix storage tubes & SepraSeal caps
- Pre-dissolved in DMSO
- Many compounds are exclusive to Tocris
- Full chemical and biological data available
- Exceptional purity
Request Compound List
To request a list of the compounds available in the Tocriscreen Kinase Inhibitor Toolbox I please click the request tile below. Compound lists can be provided in Excel or SD format.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Markussen (2018) GSK3 is a negative regulator of the thermogenic program in brown adipocytes. Sci Rep 8 3469 PMID: 29472592
Azad et al (2018) A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis. Nat.Commun. 9 PMID: 29535383
If you know of a relevant reference for Tocriscreen Kinase Inhibitor Toolbox I, please let us know.
Keywords: Tocriscreen Kinase Inhibitor Toolbox I, Tocriscreen Kinase Inhibitor Toolbox I supplier, kinases, inhibitors, inhibits, toolbox, VEGFR, AKT, CDKs, EGFR, p38, MAPK, Src, TGF-β, compound, library, libraries, screening, Tocriscreen, Toolboxes, 5933, Tocris Bioscience
3 Citations for Tocriscreen Kinase Inhibitor Toolbox I
Citations are publications that use Tocris products. Selected citations for Tocriscreen Kinase Inhibitor Toolbox I include:
Markussen et al (2018) GSK3 is a negative regulator of the thermogenic program in brown adipocytes. Sci.Rep. 8 3469 PMID: 29472592
Sandilands et al (2015) p70S6K is regulated by focal adhesion kinase and is required for Src-selective autophagy. Cell Signal. 27 1816 PMID: 26071201
Tandon et al (2015) SD-208, a novel protein kinase D inhibitor, blocks prostate cancer cell proliferation and tumor growth in vivo by inducing G2/M cell cycle arrest. PLoS One 10 e0119346 PMID: 25747583
Do you know of a great paper that uses Tocriscreen Kinase Inhibitor Toolbox I from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Compound Libraries & Toolboxes Updated
This brochure gives an overview of the unique TocriscreenTM compound libraries and toolboxes available from Tocris, including the Tocriscreen Plus, and toolboxes for the study of epigenetics, kinases and stem cells.
- Tocriscreen Plus & Plus Mini
- Custom Libraries
- FDA-Approved Compounds
- Tocriscreen Toolboxes
MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem Cell Workflow PosterNew
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.