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Aminoglycoside antibiotic. Exhibits antibacterial activity against strains of Enterobacteriaceae, Pseudomonas and Staphylococcus aureus. Shown to protect lung epithelial cells in vitro against injury from cystic fibrosis bronchial secretions and H2O2.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 467.52. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.14 mL||10.69 mL||21.39 mL|
|5 mM||0.43 mL||2.14 mL||4.28 mL|
|10 mM||0.21 mL||1.07 mL||2.14 mL|
|50 mM||0.04 mL||0.21 mL||0.43 mL|
References are publications that support the biological activity of the product.
Dienstag and Neu (1972) In vitro studies of tobramycin, an aminoglycoside antibiotic. Antimicrob.Agents Chemother. 1 41 PMID: 4670427
Cantin and Woods (1993) Protection by antibiotics against myeloperoxidase-dependent cytotoxicity to lung epithelial cells in vitro. PMID: 8380814
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Keywords: Tobramycin, Tobramycin supplier, aminoglycoside, antibiotics, antibacterial, Antibiotics, 5390, Tocris Bioscience
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Average Rating: 5 (Based on 1 Review.)
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Mechanism of action of tobramycin was studied along with other aminoglycoside antibiotics such as neomycin and gentamicin.Clinical isolate of P. aeruginosa, PAO1 (PAO1-RH) used to do susceptibility tests.
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