TMN 355

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Cat.No. 4152 - TMN 355 | C21H14ClFN2O2 | CAS No. 1186372-20-2
Description: Cyclophilin A inhibitor
Chemical Name: 2-Chloro-N-[(9H-fluoren-9-ylamino)carbonyl]-6-fluorobenzamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Potent cyclophilin A inhibitor (IC50 = 1.52 nM). Approximately 27 times more potent than cyclosporin A (Cat. No. 1101).

Compound Libraries

TMN 355 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 380.8
Formula C21H14ClFN2O2
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 1186372-20-2
PubChem ID 44249042
InChI Key SFNLLCUAISZNRV-UHFFFAOYSA-N
Smiles ClC1=C(C(NC(NC2C(C=CC=C4)=C4C3=C2C=CC=C3)=O)=O)C(F)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 15.23 40

Preparing Stock Solutions

The following data is based on the product molecular weight 380.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.63 mL 13.13 mL 26.26 mL
5 mM 0.53 mL 2.63 mL 5.25 mL
10 mM 0.26 mL 1.31 mL 2.63 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Ni et al (2009) Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach. J.Med.Chem. 52 5295 PMID: 19691347


If you know of a relevant reference for TMN 355, please let us know.

View Related Products by Target

Keywords: TMN355 cyclophilin a cypA immunosuppressants immunophilins ppiase inhibitors inhibits Miscellaneous Compounds

1 Citation for TMN 355

Citations are publications that use Tocris products. Selected citations for TMN 355 include:

Ahmed-Belkacem et al (2016) Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities. Nature Communications 7 12777 PMID: 27652979


Do you know of a great paper that uses TMN 355 from Tocris? If so please let us know.

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Literature in this Area

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New Product Guide (Spring/Summer 2017)

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Pathways for TMN 355

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