Potent cyclophilin A inhibitor (IC50 = 1.52 nM). Approximately 27 times more potent than cyclosporin A (Cat. No. 1101).
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 380.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.4 mM||6.57 mL||32.83 mL||65.65 mL|
|2 mM||1.31 mL||6.57 mL||13.13 mL|
|4 mM||0.66 mL||3.28 mL||6.57 mL|
|20 mM||0.13 mL||0.66 mL||1.31 mL|
References are publications that support the biological activity of the product.
Ni et al (2009) Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach. J.Med.Chem. 52 5295 PMID: 19691347
If you know of a relevant reference for TMN 355, please let us know.
View Related Products by Target
Keywords: TMN 355, TMN 355 supplier, TMN355, cyclophilin, a, cypA, immunosuppressants, immunophilins, ppiase, inhibitors, inhibits, Miscellaneous, Compounds, 4152, Tocris Bioscience
1 Citation for TMN 355
Citations are publications that use Tocris products. Selected citations for TMN 355 include:
Ahmed-Belkacem et al (2016) Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities. Nature Communications 7 12777 PMID: 27652979
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