TMN 355

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Cat.No. 4152 - TMN 355 | C21H14ClFN2O2 | CAS No. 1186372-20-2
Description: Cyclophilin A inhibitor
Chemical Name: 2-Chloro-N-[(9H-fluoren-9-ylamino)carbonyl]-6-fluorobenzamide
Purity: ≥98% (HPLC)
Citations (1)
Reviews (1)

Biological Activity

Potent cyclophilin A inhibitor (IC50 = 1.52 nM). Approximately 27 times more potent than cyclosporin A (Cat. No. 1101).

Technical Data

M. Wt 380.8
Formula C21H14ClFN2O2
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 1186372-20-2
PubChem ID 44249042
Smiles ClC1=C(C(NC(NC2C(C=CC=C4)=C4C3=C2C=CC=C3)=O)=O)C(F)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 15.23 40

Preparing Stock Solutions

The following data is based on the product molecular weight 380.8. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.4 mM 6.57 mL 32.83 mL 65.65 mL
2 mM 1.31 mL 6.57 mL 13.13 mL
4 mM 0.66 mL 3.28 mL 6.57 mL
20 mM 0.13 mL 0.66 mL 1.31 mL

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References are publications that support the biological activity of the product.

Ni et al (2009) Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach. J.Med.Chem. 52 5295 PMID: 19691347

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1 Citation for TMN 355

Citations are publications that use Tocris products. Selected citations for TMN 355 include:

Ahmed-Belkacem et al (2016) Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities. Nature Communications 7 12777 PMID: 27652979

Do you know of a great paper that uses TMN 355 from Tocris? Please let us know.

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We used TMN 355 to inhibit response for our study.
By Anonymous on 02/20/2019
Species: Human

Cyclophilin A is secreted from these monocytes, endothelial cells and vascular smooth muscle cells in response to inflammatory stimuli such as hyperglycemia, hypoxia, infection and oxidative stress.We used TMN 355 to inhibit such response for our study.

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