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Potent cyclophilin A inhibitor (IC50 = 1.52 nM). Approximately 27 times more potent than cyclosporin A (Cat. No. 1101).
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 380.8. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.4 mM||6.57 mL||32.83 mL||65.65 mL|
|2 mM||1.31 mL||6.57 mL||13.13 mL|
|4 mM||0.66 mL||3.28 mL||6.57 mL|
|20 mM||0.13 mL||0.66 mL||1.31 mL|
References are publications that support the biological activity of the product.
Ni et al (2009) Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach. J.Med.Chem. 52 5295 PMID: 19691347
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Keywords: TMN 355, TMN 355 supplier, TMN355, cyclophilin, a, cypA, immunosuppressants, immunophilins, ppiase, inhibitors, inhibits, Other, Isomerases, 4152, Tocris Bioscience
1 Citation for TMN 355
Citations are publications that use Tocris products. Selected citations for TMN 355 include:
Ahmed-Belkacem et al (2016) Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities. Nature Communications 7 12777 PMID: 27652979
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Reviews for TMN 355
Average Rating: 5 (Based on 1 Review.)
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Cyclophilin A is secreted from these monocytes, endothelial cells and vascular smooth muscle cells in response to inflammatory stimuli such as hyperglycemia, hypoxia, infection and oxidative stress.We used TMN 355 to inhibit such response for our study.
Literature in this Area
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