TMN 355

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Cat.No. 4152 - TMN 355 | C21H14ClFN2O2 | CAS No. 1186372-20-2
Description: Cyclophilin A inhibitor
Chemical Name: 2-Chloro-N-[(9H-fluoren-9-ylamino)carbonyl]-6-fluorobenzamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Potent cyclophilin A inhibitor (IC50 = 1.52 nM). Approximately 27 times more potent than cyclosporin A (Cat. No. 1101).

Compound Libraries

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Technical Data

M. Wt 380.8
Formula C21H14ClFN2O2
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 1186372-20-2
PubChem ID 44249042
InChI Key SFNLLCUAISZNRV-UHFFFAOYSA-N
Smiles ClC1=C(C(NC(NC2C(C=CC=C4)=C4C3=C2C=CC=C3)=O)=O)C(F)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 15.23 40

Preparing Stock Solutions

The following data is based on the product molecular weight 380.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.4 mM 6.57 mL 32.83 mL 65.65 mL
2 mM 1.31 mL 6.57 mL 13.13 mL
4 mM 0.66 mL 3.28 mL 6.57 mL
20 mM 0.13 mL 0.66 mL 1.31 mL

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References

References are publications that support the biological activity of the product.

Ni et al (2009) Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach. J.Med.Chem. 52 5295 PMID: 19691347


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View Related Products by Target

Keywords: TMN 355, TMN 355 supplier, TMN355, cyclophilin, a, cypA, immunosuppressants, immunophilins, ppiase, inhibitors, inhibits, Miscellaneous, Compounds, 4152, Tocris Bioscience

1 Citation for TMN 355

Citations are publications that use Tocris products. Selected citations for TMN 355 include:

Ahmed-Belkacem et al (2016) Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities. Nature Communications 7 12777 PMID: 27652979


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Literature in this Area

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