TL 13-110

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Cat.No. 6746 - TL 13-110 | C49H62ClN9O9S | CAS No. 2229037-09-4
Description: Negative control for TL 13-112
Chemical Name: N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-1-yl)ethoxy)ethoxy)ethyl)-2-((1,3-dioxo-2-(2-oxopiperidin-3-yl)isoindolin-4-yl)amino)acetamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Negative control for TL 13-112 (Cat. No. 6745). Displays no degradation of ALK in cell lines. Highly potent ALK inhibitor (IC50 = 0.34 nM).

Licensing Information

Sold under license from Dana-Farber Cancer Institute

Technical Data

M. Wt 988.59
Formula C49H62ClN9O9S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2229037-09-4
Smiles CC(C)OC1=CC(C2CCN(CCOCCOCCNC(CNC3=CC=CC4=C3C(N(C5CCCNC5=O)C4=O)=O)=O)CC2)=C(C)C=C1NC6=NC=C(Cl)C(NC7=CC=CC=C7S(=O)(C(C)C)=O)=N6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 49.43 50

Preparing Stock Solutions

The following data is based on the product molecular weight 988.59. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 2.02 mL 10.12 mL 20.23 mL
2.5 mM 0.4 mL 2.02 mL 4.05 mL
5 mM 0.2 mL 1.01 mL 2.02 mL
25 mM 0.04 mL 0.2 mL 0.4 mL

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References

References are publications that support the biological activity of the product.

Powell et al (2018) Chemically induced degradation of anaplastic lymphoma kinase. J.Med.Chem. 61 4249 PMID: 29660984


If you know of a relevant reference for TL 13-110, please let us know.

Keywords: TL 13-110, TL 13-110 supplier, TL13-110, PROTAC, Proteolysis, targeted, chimeras, cereblon, E3, ubiquitin, ligase, ALK, inhibitors, negative, control, TPD, protein, degradation, Active, Degraders, 6746, Tocris Bioscience

Citations for TL 13-110

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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