Discontinued Product

Tipifarnib (Cat. No. 6410) has been withdrawn from sale for commercial reasons.
Description: Potent farnesyltransferase inhibitor; orally bioavailable
Chemical Name: 6-[(R)-Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl}-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone
Purity: ≥98% (HPLC)

Biological Activity for Tipifarnib

Tipifarnib is a potent farnesyltransferase inhibitor. Inhibits farnesylation of lamin B and K-RasB peptide substrates (IC50 values are 0.86 and 7.9 nM, respectively). Inhibits tumor growth in vitro and in vivo. Cell penetrant and orally bioavailable.

Technical Data for Tipifarnib

M. Wt 489.4
Formula C27H22Cl2N4O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 192185-72-1
PubChem ID 159324
Smiles CN1C=NC=C1[C@@](C2=CC=C(C=C2)Cl)(C3=CC=C4N(C(C=C(C4=C3)C5=CC(Cl)=CC=C5)=O)C)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Tipifarnib

References are publications that support the biological activity of the product.

End et al (2001) Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro. Cancer Res. 61 131 PMID: 11196150

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Citations for Tipifarnib

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Currently there are no citations for Tipifarnib.

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