Tipifarnib

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Cat.No. 6410 - Tipifarnib | C27H22Cl2N4O | CAS No. 192185-72-1
Description: Potent farnesyltransferase inhibitor; orally bioavailable
Chemical Name: 6-[(R)-Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl}-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent farnesyltransferase inhibitor. Inhibits farnesylation of lamin B and K-RasB peptide substrates (IC50 values are 0.86 and 7.9 nM, respectively). Inhibits tumor growth in vitro and in vivo. Cell penetrant and orally bioavailable.

Technical Data

M. Wt 489.4
Formula C27H22Cl2N4O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 192185-72-1
PubChem ID 159324
InChI Key PLHJCIYEEKOWNM-HHHXNRCGSA-N
Smiles CN1C=NC=C1[C@@](C2=CC=C(C=C2)Cl)(C3=CC=C4N(C(C=C(C4=C3)C5=CC(Cl)=CC=C5)=O)C)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 48.94 100
ethanol 9.79 20

Preparing Stock Solutions

The following data is based on the product molecular weight 489.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.04 mL 10.22 mL 20.43 mL
5 mM 0.41 mL 2.04 mL 4.09 mL
10 mM 0.2 mL 1.02 mL 2.04 mL
50 mM 0.04 mL 0.2 mL 0.41 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

End et al (2001) Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro. Cancer Res. 61 131 PMID: 11196150


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Cancer

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