Pricing Availability   Qty
Description: Potent farnesyltransferase inhibitor; orally bioavailable
Chemical Name: 6-[(R)-Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl}-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for Tipifarnib

Tipifarnib is a potent farnesyltransferase inhibitor. Inhibits farnesylation of lamin B and K-RasB peptide substrates (IC50 values are 0.86 and 7.9 nM, respectively). Inhibits tumor growth in vitro and in vivo. Cell penetrant and orally bioavailable.

Technical Data for Tipifarnib

M. Wt 489.4
Formula C27H22Cl2N4O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 192185-72-1
PubChem ID 159324
Smiles CN1C=NC=C1[C@@](C2=CC=C(C=C2)Cl)(C3=CC=C4N(C(C=C(C4=C3)C5=CC(Cl)=CC=C5)=O)C)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Tipifarnib

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 48.94 100
ethanol 9.79 20

Preparing Stock Solutions for Tipifarnib

The following data is based on the product molecular weight 489.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.04 mL 10.22 mL 20.43 mL
5 mM 0.41 mL 2.04 mL 4.09 mL
10 mM 0.2 mL 1.02 mL 2.04 mL
50 mM 0.04 mL 0.2 mL 0.41 mL

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References for Tipifarnib

References are publications that support the biological activity of the product.

End et al (2001) Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro. Cancer Res. 61 131 PMID: 11196150

If you know of a relevant reference for Tipifarnib, please let us know.

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Citations for Tipifarnib

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Literature in this Area

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Cancer Research Product Guide

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

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