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Discontinued ProductTipifarnib (Cat. No. 6410) has been withdrawn from sale for commercial reasons.
Biological Activity for Tipifarnib
Tipifarnib is a potent farnesyltransferase inhibitor. Inhibits farnesylation of lamin B and K-RasB peptide substrates (IC50 values are 0.86 and 7.9 nM, respectively). Inhibits tumor growth in vitro and in vivo. Cell penetrant and orally bioavailable.
Technical Data for Tipifarnib
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References for Tipifarnib
References are publications that support the biological activity of the product.
End et al (2001) Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro. Cancer Res. 61 131 PMID: 11196150
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Keywords: Tipifarnib, Tipifarnib supplier, Potent, farnesyltransferase, inhibitors, inhibits, antitumor, cell, penetrant, orally, bioavailable, Protein, Prenyltransferases, Post-translational, Modifications, 6410, Tocris Bioscience
Citations for Tipifarnib
Citations are publications that use Tocris products.
Currently there are no citations for Tipifarnib.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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