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Discontinued Product
Tipifarnib (Cat. No. 6410) has been withdrawn from sale for commercial reasons.
Description: Potent farnesyltransferase inhibitor; orally bioavailable
Chemical Name: 6-[(R)-Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl}-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone
Purity: ≥98% (HPLC)
Biological Activity for Tipifarnib
Tipifarnib is a potent farnesyltransferase inhibitor. Inhibits farnesylation of lamin B and K-RasB peptide substrates (IC50 values are 0.86 and 7.9 nM, respectively). Inhibits tumor growth in vitro and in vivo. Cell penetrant and orally bioavailable.
Technical Data for Tipifarnib
| M. Wt | 489.4 |
| Formula | C27H22Cl2N4O |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 192185-72-1 |
| PubChem ID | 159324 |
| InChI Key | PLHJCIYEEKOWNM-HHHXNRCGSA-N |
| Smiles | CN1C=NC=C1[C@@](C2=CC=C(C=C2)Cl)(C3=CC=C4N(C(C=C(C4=C3)C5=CC(Cl)=CC=C5)=O)C)N |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Tipifarnib
References for Tipifarnib
References are publications that support the biological activity of the product.
End et al (2001) Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro. Cancer Res. 61 131 PMID: 11196150
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Citations for Tipifarnib
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Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Angiogenesis
- Invasion and Metastasis