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Tiotropium bromide

Cat. No. 5902 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent muscarinic receptor antagonist
Alternative Names: Ba 679 BR
Chemical Name: (1α,2β,4β,5α,7β)-7-[(2-Hydroxy-2,2-di-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Tiotropium bromide

Tiotropium bromide is a potent muscarinic receptor antagonist. Inhibits electrical field stimulation-induced contraction of guinea pig trachea in vitro (IC50 = 0.17 nM). Induces smooth muscle relaxation and bronchodilation.

Compound Libraries for Tiotropium bromide

Tiotropium bromide is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Tiotropium bromide

M. Wt 472.42
Formula C19H22BrNO4S2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 136310-93-5
PubChem ID 5487426
InChI Key DQHNAVOVODVIMG-RGECMCKFSA-M
Smiles C[N+]1(C)[C@]2([H])[C@H]3[C@H](O3)[C@@]1([H])C[C@@H](OC(C(C4=CC=CS4)(O)C5=CC=CS5)=O)C2.[Br-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Tiotropium bromide

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 9.45 20
DMSO 47.24 100

Preparing Stock Solutions for Tiotropium bromide

The following data is based on the product molecular weight 472.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.12 mL 10.58 mL 21.17 mL
5 mM 0.42 mL 2.12 mL 4.23 mL
10 mM 0.21 mL 1.06 mL 2.12 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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Product Datasheets for Tiotropium bromide

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for Tiotropium bromide

References are publications that support the biological activity of the product.

Takahashi et al (1994) Effect of Ba 679 BR, a novel long-acting anticholin. agent, on cholinergic neurotransmission in guinea pig and human airways. Am.J.Respir.Crit.Care Med. 150 1640 PMID: 7952627

Smit et al (2014) Bronchoprotection by olodaterol is synergistically enhanced by tiotr. in a guinea pig model of allergic asthma. J.Pharmacol.Exp.Ther. 348 303 PMID: 24307202

Ogoda et al (2011) Comparative characterization of lung muscarinic receptor binding after intratracheal administration of tiotropium, ipratropium, and glycopyrr. J.Pharm.Sci. 115 374 PMID: 21358117

If you know of a relevant reference for Tiotropium bromide, please let us know.

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Citations for Tiotropium bromide

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Literature in this Area

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