Tiotropium bromide

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Cat.No. 5902 - Tiotropium bromide | C19H22BrNO4S2 | CAS No. 136310-93-5
Description: Potent muscarinic receptor antagonist
Alternative Names: Ba 679 BR
Chemical Name: (1α,2β,4β,5α,7β)-7-[(2-Hydroxy-2,2-di-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent muscarinic receptor antagonist. Inhibits electrical field stimulation-induced contraction of guinea pig trachea in vitro (IC50 = 0.17 nM). Induces smooth muscle relaxation and bronchodilation.

Technical Data

M. Wt 472.42
Formula C19H22BrNO4S2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 136310-93-5
PubChem ID 5487426
InChI Key DQHNAVOVODVIMG-RGECMCKFSA-M
Smiles C[N+]1(C)[C@]2([H])[C@H]3[C@H](O3)[C@@]1([H])C[C@@H](OC(C(C4=CC=CS4)(O)C5=CC=CS5)=O)C2.[Br-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 9.45 20
DMSO 47.24 100

Preparing Stock Solutions

The following data is based on the product molecular weight 472.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.12 mL 10.58 mL 21.17 mL
5 mM 0.42 mL 2.12 mL 4.23 mL
10 mM 0.21 mL 1.06 mL 2.12 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Takahashi et al (1994) Effect of Ba 679 BR, a novel long-acting anticholinergic agent, on cholinergic neurotransmission in guinea pig and human airways. Am.J.Respir.Crit.Care Med. 150 1640 PMID: 7952627

Smit et al (2014) Bronchoprotection by olodaterol is synergistically enhanced by tiotropium in a guinea pig model of allergic asthma. J.Pharmacol.Exp.Ther. 348 303 PMID: 24307202

Ogoda et al (2011) Comparative characterization of lung muscarinic receptor binding after intratracheal administration of tiotropium, ipratropium, and glycopyrrolate. J.Pharm.Sci. 115 374 PMID: 21358117


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Keywords: Tiotropium bromide, supplier, Ba679BR, potent, muscarinic, receptors, antagonists, M1, M2, M3, M4, Ba, 679, BR, Non-selective, Muscarinics, Non-selective, Muscarinics, Tocris Bioscience

Citations for Tiotropium bromide

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