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Submit ReviewTiotropium bromide
Description: Potent muscarinic receptor antagonist
Alternative Names: Ba 679 BR
Chemical Name: (1α,2β,4β,5α,7β)-7-[(2-Hydroxy-2,2-di-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide
Purity: ≥98% (HPLC)
Biological Activity
Potent muscarinic receptor antagonist. Inhibits electrical field stimulation-induced contraction of guinea pig trachea in vitro (IC50 = 0.17 nM). Induces smooth muscle relaxation and bronchodilation.
Technical Data
| M. Wt | 472.42 |
| Formula | C19H22BrNO4S2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 136310-93-5 |
| PubChem ID | 5487426 |
| InChI Key | DQHNAVOVODVIMG-RGECMCKFSA-M |
| Smiles | C[N+]1(C)[C@]2([H])[C@H]3[C@H](O3)[C@@]1([H])C[C@@H](OC(C(C4=CC=CS4)(O)C5=CC=CS5)=O)C2.[Br-] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 9.45 | 20 | |
| DMSO | 47.24 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 472.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.12 mL | 10.58 mL | 21.17 mL |
| 5 mM | 0.42 mL | 2.12 mL | 4.23 mL |
| 10 mM | 0.21 mL | 1.06 mL | 2.12 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.42 mL |
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References
References are publications that support the biological activity of the product.
Takahashi et al (1994) Effect of Ba 679 BR, a novel long-acting anticholin. agent, on cholinergic neurotransmission in guinea pig and human airways. Am.J.Respir.Crit.Care Med. 150 1640 PMID: 7952627
Smit et al (2014) Bronchoprotection by olodaterol is synergistically enhanced by tiotr. in a guinea pig model of allergic asthma. J.Pharmacol.Exp.Ther. 348 303 PMID: 24307202
Ogoda et al (2011) Comparative characterization of lung muscarinic receptor binding after intratracheal administration of tiotropium, ipratropium, and glycopyrr. J.Pharm.Sci. 115 374 PMID: 21358117
If you know of a relevant reference for Tiotropium bromide, please let us know.
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Keywords: Tiotropium bromide, Tiotropium bromide supplier, Ba679BR, potent, muscarinic, receptors, antagonists, M1, M2, M3, M4, Ba, 679, BR, Non-selective, Muscarinics, 5902, Tocris Bioscience
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