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Cat.No. 0826 - Tiotidine | C10H16N8S2 | CAS No. 69014-14-8
Description: Potent, selective H2 antagonist
Alternative Names: ICI 125,211
Purity: ≥99% (HPLC)
Citations (2)

Biological Activity

Potent histamine H2-receptor antagonist with negligible activity against H1- and H3- receptors.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Compound Libraries

Tiotidine is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 312.41
Formula C10H16N8S2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 69014-14-8
PubChem ID 50287
Smiles CN\C(NCCSCC1=CSC(\N=C(/N)N)=N1)=N/C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 10 mM in ethanol and to 100 mM in DMSO

Preparing Stock Solutions

The following data is based on the product molecular weight 312.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.2 mL 16 mL 32.01 mL
5 mM 0.64 mL 3.2 mL 6.4 mL
10 mM 0.32 mL 1.6 mL 3.2 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Hill (1990) Distribution, properties, and functional characteristics of three classes of histamine receptor. Pharmacol.Rev. 42 45 PMID: 2164693

Trzeciakowski and Levi (1980) The cardiac pharmacology of tiotidine (ICI 125,211): A new histamine H2- receptor antagonist. J.Pharmacol.Exp.Ther. 214 629 PMID: 6105207

Yellin et al (1979) ICI 125,211: A new gastric antisecretory agent acting on histamine H2- receptors. Life Sci. 25 2001 PMID: 43449

If you know of a relevant reference for Tiotidine, please let us know.

View Related Products by Target

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View all Histamine H2 Receptor Antagonists

Keywords: Tiotidine, supplier, Potent, selective, H2, antagonists, Receptors, Histamine, histaminergic, AstraZeneca, ICI125211, ICI, 125,211, Histamine, H2, Receptors, Histamine, H2, Receptors, Tocris Bioscience

2 Citations for Tiotidine

Citations are publications that use Tocris products. Selected citations for Tiotidine include:

Alonso et al (2015) Physiological implications of biased signaling at histamine H2 receptors. Exp Ther Med 6 45 PMID: 25805997

Holden et al (2007) Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells. Front Pharmacol 152 891 PMID: 17891168

Do you know of a great paper that uses Tiotidine from Tocris? If so please let us know.

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