Tiotidine

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Cat.No. 0826 - Tiotidine | C10H16N8S2 | CAS No. 69014-14-8
Description: Potent and selective H2 antagonist
Alternative Names: ICI 125,211
Purity: ≥99% (HPLC)
Datasheet
Citations (4)
Reviews
Literature

Biological Activity

Potent histamine H2-receptor antagonist with negligible activity against H1- and H3- receptors.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Compound Libraries

Tiotidine is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 312.41
Formula C10H16N8S2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 69014-14-8
PubChem ID 50287
InChI Key YDDXVAXDYKBWDX-UHFFFAOYSA-N
Smiles CN\C(NCCSCC1=CSC(\N=C(/N)N)=N1)=N/C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 10 mM in ethanol and to 100 mM in DMSO

References

References are publications that support the biological activity of the product.

Hill (1990) Distribution, properties, and functional characteristics of three classes of histamine receptor. Pharmacol.Rev. 42 45 PMID: 2164693

Trzeciakowski and Levi (1980) The cardiac pharmacology of tiotidine (ICI 125,211): A new histamine H2- receptor antagonist. J.Pharmacol.Exp.Ther. 214 629 PMID: 6105207

Yellin et al (1979) ICI 125,211: A new gastric antisecretory agent acting on histamine H2- receptors. Life Sci. 25 2001 PMID: 43449


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Keywords: Tiotidine, Tiotidine supplier, Potent, selective, H2, antagonists, Receptors, Histamine, histaminergic, AstraZeneca, ICI125211, ICI, 125,211, 0826, Tocris Bioscience

4 Citations for Tiotidine

Citations are publications that use Tocris products. Selected citations for Tiotidine include:

Holden et al (2007) Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells. Front Pharmacol 152 891 PMID: 17891168

Alonso et al (2015) Physiological implications of biased signaling at histamine H2 receptors. Exp Ther Med 6 45 PMID: 25805997

Flamand et al (2004) Histamine-induced inhibition of leukotriene biosynthesis in human neutrophils: involvement of the H2 receptor and cAMP. Br J Pharmacol 141 552 PMID: 14744809

Chigaev et al (2011) Real-time analysis of the inside-out regulation of lymphocyte function-associated antigen-1 revealed similarities to and differences from very late antigen-4. J Biol Chem 286 20375 PMID: 21515675


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