Tianeptine sodium salt

Pricing Availability Delivery Time Qty
Cat.No. 1972 - Tianeptine sodium salt | C21H24ClN2NaO4S | CAS No. 30123-17-2
Description: Selective facilitator of 5-HT uptake; antidepressant
Chemical Name: 7-[(3-Chloro-6,11-dihydro-6-methyl-5,5-dioxidodibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid sodium salt
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews
Literature

Biological Activity

Selective facilitator of 5-HT uptake in vitro and in vivo. Has no affinity for a wide range of receptors, including 5-HT and dopamine (IC50 > 10 μM) and has no effect on noradrenalin or dopamine uptake. Antidepressant, analgesic and neuroprotective following systemic administration in vivo.

Technical Data

M. Wt 458.93
Formula C21H24ClN2NaO4S
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 30123-17-2
PubChem ID 23663953
InChI Key ZLBSUOGMZDXYKE-UHFFFAOYSA-M
Smiles [Na+].CN1C2=CC=CC=C2C(NCCCCCCC([O-])=O)C2=CC=C(Cl)C=C2S1(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.58 10
ethanol 4.58 10
water 45.89 100

Preparing Stock Solutions

The following data is based on the product molecular weight 458.93. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.18 mL 10.89 mL 21.79 mL
5 mM 0.44 mL 2.18 mL 4.36 mL
10 mM 0.22 mL 1.09 mL 2.18 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Kato and Weitsch (1988) Neurochemical profile of tianeptine, a new antidepressant drug. Clin.Neuropharmacol. 11 S43 PMID: 3052825

Uzbay et al (1999) Analgesic effect of tianeptine in mice. Life Sci. 64 1313 PMID: 10227587

Plaisant et al (2003) Neuroprotective properties of tianeptine: interactions with cytokines. Neuropharmacology 44 801 PMID: 12681378

Mennini et al (1987) Tianeptine, a selective enhancer of serotonin uptake in rat brain. Naunyn-Schmied.Arch.Pharmacol. 336 478 PMID:


If you know of a relevant reference for Tianeptine sodium salt, please let us know.

View Related Products by Target

Keywords: Tianeptine sodium salt, supplier, Selective, facilitator, 5-HT, reuptake, antidepressant, Serotonin, Transporters, SERT, 5-Hydroxytryptamine, Monoamine, Neurotransmitter, 5-HT, Transporters, 5-HT, Transporters, Tocris Bioscience

2 Citations for Tianeptine sodium salt

Citations are publications that use Tocris products. Selected citations for Tianeptine sodium salt include:

Czysz et al (2015) Lateral diffusion of Gαs in the plasma membrane is decreased after chronic but not acute antidepressant treatment: role of lipid raft and non-raft membrane microdomains. Nature 40 766 PMID: 25249058

Makani et al (2013) Tianeptine interferes with microtubule organization and hormone secretion of pheochromocytoma cells. Mol Cell Endocrinol 381 175 PMID: 23933152


Do you know of a great paper that uses Tianeptine sodium salt from Tocris? If so please let us know.

Reviews for Tianeptine sodium salt

There are currently no reviews for this product. Be the first to review Tianeptine sodium salt and earn rewards!

Have you used Tianeptine sodium salt?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area

Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.