Tianeptine sodium salt

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Cat.No. 1972 - Tianeptine sodium salt | C21H24ClN2NaO4S | CAS No. 30123-17-2
Description: Selective facilitator of 5-HT uptake; antidepressant
Chemical Name: 7-[(3-Chloro-6,11-dihydro-6-methyl-5,5-dioxidodibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid sodium salt
Purity: ≥99% (HPLC)
Citations (2)

Biological Activity

Selective facilitator of 5-HT uptake in vitro and in vivo. Has no affinity for a wide range of receptors, including 5-HT and dopamine (IC50 > 10 μM) and has no effect on noradrenalin or dopamine uptake. Antidepressant, analgesic and neuroprotective following systemic administration in vivo.

Technical Data

M. Wt 458.93
Formula C21H24ClN2NaO4S
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 30123-17-2
PubChem ID 23663953
Smiles [Na+].CN1C2=CC=CC=C2C(NCCCCCCC([O-])=O)C2=CC=C(Cl)C=C2S1(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 4.58 10
water 45.89 100

Preparing Stock Solutions

The following data is based on the product molecular weight 458.93. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.18 mL 10.89 mL 21.79 mL
5 mM 0.44 mL 2.18 mL 4.36 mL
10 mM 0.22 mL 1.09 mL 2.18 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Kato and Weitsch (1988) Neurochemical profile of tianeptine, a new antidepressant drug. Clin.Neuropharmacol. 11 S43 PMID: 3052825

Uzbay et al (1999) Analgesic effect of tianeptine in mice. Life Sci. 64 1313 PMID: 10227587

Plaisant et al (2003) Neuroprotective properties of tianeptine: interactions with cytokines. Neuropharmacology 44 801 PMID: 12681378

Mennini et al (1987) Tianeptine, a selective enhancer of serotonin uptake in rat brain. Naunyn-Schmied.Arch.Pharmacol. 336 478

If you know of a relevant reference for Tianeptine sodium salt, please let us know.

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Keywords: Tianeptine sodium salt, Tianeptine sodium salt supplier, Selective, facilitator, 5-HT, reuptake, antidepressant, Serotonin, Transporters, SERT, 5-Hydroxytryptamine, Monoamine, Neurotransmitter, 1972, Tocris Bioscience

2 Citations for Tianeptine sodium salt

Citations are publications that use Tocris products. Selected citations for Tianeptine sodium salt include:

Makani et al (2013) Tianeptine interferes with microtubule organization and hormone secretion of pheochromocytoma cells. Mol Cell Endocrinol 381 175 PMID: 23933152

Czysz et al (2015) Lateral diffusion of Gαs in the plasma membrane is decreased after chronic but not acute antidepressant treatment: role of lipid raft and non-raft membrane microdomains. Nature 40 766 PMID: 25249058

Do you know of a great paper that uses Tianeptine sodium salt from Tocris? Please let us know.

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