Tianeptine sodium salt
Selective facilitator of 5-HT uptake in vitro and in vivo. Has no affinity for a wide range of receptors, including 5-HT and dopamine (IC50 > 10 μM) and has no effect on noradrenalin or dopamine uptake. Antidepressant, analgesic and neuroprotective following systemic administration in vivo.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 458.93. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.18 mL||10.89 mL||21.79 mL|
|5 mM||0.44 mL||2.18 mL||4.36 mL|
|10 mM||0.22 mL||1.09 mL||2.18 mL|
|50 mM||0.04 mL||0.22 mL||0.44 mL|
References are publications that support the products' biological activity.
Kato and Weitsch (1988) Neurochemical profile of tianeptine, a new antidepressant drug. Clin.Neuropharmacol. 11 S43 PMID: 3052825
Uzbay et al (1999) Analgesic effect of tianeptine in mice. Life Sci. 64 1313 PMID: 10227587
Plaisant et al (2003) Neuroprotective properties of tianeptine: interactions with cytokines. Neuropharmacology 44 801 PMID: 12681378
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Keywords: Tianeptine sodium salt, supplier, Selective, facilitator, 5-HT, reuptake, antidepressant, Serotonin, Transporters, SERT, 5-Hydroxytryptamine, Monoamine, Neurotransmitter, 5-HT, Transporters, 5-HT, Transporters, Tocris Bioscience
2 Citations for Tianeptine sodium salt
Citations are publications that use Tocris products. Selected citations for Tianeptine sodium salt include:
Czysz et al (2015) Lateral diffusion of Gαs in the plasma membrane is decreased after chronic but not acute antidepressant treatment: role of lipid raft and non-raft membrane microdomains. Nature 40 766 PMID: 25249058
Makani et al (2013) Tianeptine interferes with microtubule organization and hormone secretion of pheochromocytoma cells. Mol Cell Endocrinol 381 175 PMID: 23933152
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
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5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.