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Potent, selective inhibitor of O-GlcNAcase (Ki = 21 nM for human O-GlcNAcase). Decreases the phosphorylation of tau protein in vivo. Promotes autophagy independently of mTOR pathway and reduces toxic protein species in mouse tauopathy model. Orally bioavailable and blood brain barrier permeable.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 248.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||8.05 mL||40.27 mL||80.55 mL|
|2.5 mM||1.61 mL||8.05 mL||16.11 mL|
|5 mM||0.81 mL||4.03 mL||8.05 mL|
|25 mM||0.16 mL||0.81 mL||1.61 mL|
References are publications that support the biological activity of the product.
Yuzwa et al (2008) A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo. Nat.Chem.Biol. 4 483 PMID: 18587388
Zhu et al (2018) Pharmacological inhibition of O-GlcNAcase enhances autophagy in brain through an mTOR-independent pathway ACS Chem.Neurosci. 9 1366 PMID: 29460617
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Keywords: Thiamet G, Thiamet G supplier, glycosidase, O-GlcNAc-beta-N-acetylglucosaminidase, inhibitors, inhibits, O-GlcNAcase, ThiametG, Other, Hydrolases, 4390, Tocris Bioscience
3 Citations for Thiamet G
Citations are publications that use Tocris products. Selected citations for Thiamet G include:
Hayakawa et al (2013) Epigenetic switching by the metabolism-sensing factors in the generation of orexin neurons from mouse embryonic stem cells. J Biol Chem 288 17099 PMID: 23625921
Taparra et al (2018) O-GlcNAcylation is required for mutant KRAS-induced lung tumorigenesis. J Clin Invest 128 4924 PMID: 30130254
Maury et al (2013) Excess of O-linked N-acetylglucosamine modifies human pluripotent stem cell differentiation. Stem Cell Res 11 926 PMID: 23859804
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