Thiamet G

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Cat.No. 4390 - Thiamet G | C9H16N2O4S | CAS No. 1009816-48-1
Description: Potent O-GlcNAcase inhibitor
Chemical Name: (3aR,5R,6S,7R,7aR)-2-(Ethylamino)-3a,6,7,7a-tetrahydro-5-(hydroxymethyl)-5H-pyrano[3,2-d]thiazole-6,7-diol
Datasheet
Citations (1)
Literature

Biological Activity

Potent, selective inhibitor of O-GlcNAcase (Ki = 21 nM for human O-GlcNAcase). Decreases the phosphorylation of tau protein in vivo. Orally bioavailable and blood brain barrier permeable.

Compound Libraries

Thiamet G is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 248.3
Formula C9H16N2O4S
Storage Store at -20°C
CAS Number 1009816-48-1
PubChem ID 24808478
InChI Key PPAIMZHKIXDJRN-FMDGEEDCSA-N
Smiles CCNC2=N[C@]1([H])[C@@H](O)[C@H](O)[C@@H](CO)O[C@@]([H])1S2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 12.41 50

Preparing Stock Solutions

The following data is based on the product molecular weight 248.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.03 mL 20.14 mL 40.27 mL
5 mM 0.81 mL 4.03 mL 8.05 mL
10 mM 0.4 mL 2.01 mL 4.03 mL
50 mM 0.08 mL 0.4 mL 0.81 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Yuzwa et al (2008) A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo. Nat.Chem.Biol. 4 483 PMID: 18587388


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View all Other Hydrolase Inhibitors

Keywords: glycosidase O-GlcNAc-beta-N-acetylglucosaminidase inhibitors inhibits O-GlcNAcase ThiametG Other Hydrolases

1 Citation for Thiamet G

Citations are publications that use Tocris products. Selected citations for Thiamet G include:

Hayakawa et al (2013) Epigenetic switching by the metabolism-sensing factors in the generation of orexin neurons from mouse embryonic stem cells. J Biol Chem 288 17099 PMID: 23625921


Do you know of a great paper that uses Thiamet G from Tocris? If so please let us know.

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Literature in this Area

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

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  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Pathways for Thiamet G

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