Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewTheophylline
Description: Adenosine receptor antagonist; bronchodilator
Chemical Name: 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione
Purity: ≥99% (HPLC)
Biological Activity
Bronchodilator, anti-inflammatory and immunomodulator. Antagonizes adenosine receptors and is a weak non-selective inhibitor of phosphodiesterases (PDEs).
Technical Data
| M. Wt | 180.16 |
| Formula | C7H8N4O2 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 58-55-9 |
| PubChem ID | 2153 |
| InChI Key | ZFXYFBGIUFBOJW-UHFFFAOYSA-N |
| Smiles | O=C1C2=C(N=CN2)N(C)C(N1C)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 4.5 | 25 | |
| DMSO | 18.02 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 180.16. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.55 mL | 27.75 mL | 55.51 mL |
| 5 mM | 1.11 mL | 5.55 mL | 11.1 mL |
| 10 mM | 0.56 mL | 2.78 mL | 5.55 mL |
| 50 mM | 0.11 mL | 0.56 mL | 1.11 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets
References
References are publications that support the biological activity of the product.
Page (1999) Recent advances in our understanding of the use of theophy. in the treatment of asthma. J.Clin.Pharmacol. 39 237 PMID: 10073321
Coward et al (1998) Asthma, adenosine, mast cells and theophy. Clin.Exp.Allery 28 42
Barnes (2003) Theophylline. New perspectives for an old drug. Am.J.Respir.Care Med. 167 813
If you know of a relevant reference for Theophylline, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Theophylline, Theophylline supplier, Phosphodiesterases, inhibitors, inhibits, adenosines, receptor, antagonists, bronchodilator, PDE, Non-Selective, Receptors, Non-selective, Adenosine, 2795, Tocris Bioscience
Citations for Theophylline
Citations are publications that use Tocris products.
Currently there are no citations for Theophylline. Do you know of a great paper that uses Theophylline from Tocris? Please let us know.
Reviews for Theophylline
There are currently no reviews for this product. Be the first to review Theophylline and earn rewards!
Have you used Theophylline?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cardiovascular Research Product Guide
A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:
- Hypertension
- Thrombosis and Hemostasis
- Atherosclerosis
- Myocardial Infarction
- Ischemia/Reperfusion Injury
- Arrhythmias
- Heart Failure
GPCR Product Listing
A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:
- Rhodopsin-like Receptors
- Glutamate Receptors
- Frizzled Receptors
- GPCR Signaling
Pain Research Product Guide
A collection of over 280 products for pain research, the guide includes research tools for the study of:
- Nociception
- Ion Channels
- G-Protein-Coupled Receptors
- Intracellular Signaling
Cardiovascular Poster
Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.