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Submit ReviewTheophylline
Description: Adenosine receptor antagonist; bronchodilator
Chemical Name: 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione
Purity: ≥99% (HPLC)
Biological Activity
Bronchodilator, anti-inflammatory and immunomodulator. Antagonizes adenosine receptors and is a weak non-selective inhibitor of phosphodiesterases (PDEs).
Technical Data
| M. Wt | 180.16 |
| Formula | C7H8N4O2 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 58-55-9 |
| PubChem ID | 2153 |
| InChI Key | ZFXYFBGIUFBOJW-UHFFFAOYSA-N |
| Smiles | O=C1C2=C(N=CN2)N(C)C(N1C)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 4.5 | 25 | |
| DMSO | 18.02 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 180.16. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.55 mL | 27.75 mL | 55.51 mL |
| 5 mM | 1.11 mL | 5.55 mL | 11.1 mL |
| 10 mM | 0.56 mL | 2.78 mL | 5.55 mL |
| 50 mM | 0.11 mL | 0.56 mL | 1.11 mL |
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Product Datasheets
References
References are publications that support the biological activity of the product.
Page (1999) Recent advances in our understanding of the use of theophy. in the treatment of asthma. J.Clin.Pharmacol. 39 237 PMID: 10073321
Coward et al (1998) Asthma, adenosine, mast cells and theophy. Clin.Exp.Allery 28 42
Barnes (2003) Theophylline. New perspectives for an old drug. Am.J.Respir.Care Med. 167 813
If you know of a relevant reference for Theophylline, please let us know.
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Keywords: Theophylline, Theophylline supplier, Phosphodiesterases, inhibitors, inhibits, adenosines, receptor, antagonists, bronchodilator, PDE, Non-Selective, Receptors, Non-selective, Adenosine, 2795, Tocris Bioscience
Citations for Theophylline
Citations are publications that use Tocris products.
Currently there are no citations for Theophylline. Do you know of a great paper that uses Theophylline from Tocris? Please let us know.
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