Theophylline

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Cat.No. 2795 - Theophylline | C7H8N4O2 | CAS No. 58-55-9
Description: Adenosine receptor antagonist; bronchodilator
Chemical Name: 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione
Purity: ≥99% (HPLC)
Datasheet
Citations

Biological Activity

Bronchodilator, anti-inflammatory and immunomodulator. Antagonizes adenosine receptors and is a weak non-selective inhibitor of phosphodiesterases (PDEs).

Technical Data

M. Wt 180.16
Formula C7H8N4O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 58-55-9
PubChem ID 2153
InChI Key ZFXYFBGIUFBOJW-UHFFFAOYSA-N
Smiles O=C1C2=C(N=CN2)N(C)C(N1C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1.1eq. NaOH 18.02 100
1eq. HCl 4.5 25
DMSO 18.02 100
ethanol 1.8 10
water 4.5 25

Preparing Stock Solutions

The following data is based on the product molecular weight 180.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.55 mL 27.75 mL 55.51 mL
5 mM 1.11 mL 5.55 mL 11.1 mL
10 mM 0.56 mL 2.78 mL 5.55 mL
50 mM 0.11 mL 0.56 mL 1.11 mL

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Page (1999) Recent advances in our understanding of the use of theophylline in the treatment of asthma. J.Clin.Pharmacol. 39 237 PMID: 10073321

Coward et al (1998) Asthma, adenosine, mast cells and theophylline. Clin.Exp.Allery 28 42 PMID:

Barnes (2003) Theophylline. New perspectives for an old drug. Am.J.Respir.Care Med. 167 813 PMID:


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Keywords: Phosphodiesterases inhibitors inhibits adenosines receptor antagonists bronchodilator PDE Non-Selective Receptors Non-selective Adenosine

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