Thalidomide - linker 6

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Cat.No. 6850 - Thalidomide - linker 6 | C15H15N3O5.HCl
Description: Thalidomide-alkylC2-Amine
Chemical Name: 4-(2-Aminoethoxy)-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Functionalized cereblon ligand for PROTAC research and development; incorporates an E3 ligase ligand plus an alkylC2 linker with terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

Technical Data

M. Wt 353.76
Formula C15H15N3O5.HCl
Storage Store at -20°C
Purity ≥95% (HPLC)
Smiles NCCOC1=C2C(N(C(C2=CC=C1)=O)C3CCC(NC3=O)=O)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.38 100
DMF 35.38 100

Preparing Stock Solutions

The following data is based on the product molecular weight 353.76. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.83 mL 14.13 mL 28.27 mL
5 mM 0.57 mL 2.83 mL 5.65 mL
10 mM 0.28 mL 1.41 mL 2.83 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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References

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Keywords: Thalidomide - linker 6, Thalidomide - linker 6 supplier, Proteolysis, Targeting, Chimera, PROTAC, degraders, cereblon, E3, ubiquitin, ligase, AlkylC2, linker, conjugate, building, block, ligands, 390367-50-7, Cereblon, Ligands, Plus, Linkers, 6850, Tocris Bioscience

Citations for Thalidomide - linker 6

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Literature in this Area

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Targeted Protein Degradation

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed.