Thalidomide - linker 4

Pricing Availability   Qty
Cat.No. 6627 - Thalidomide - linker 4 | C19H23N3O5.HCl | CAS No. 2245697-88-3
Description: Thalidomide-alkylC6-amine
Chemical Name: 4-[(6-Aminohexyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride
Purity: ≥95% (HPLC)

Biological Activity

Functionalized cereblon ligand for PROTAC research and development; incorporates an E3 ligase ligand plus a C6 alkyl linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTACs R&D.

Technical Data

M. Wt 409.86
Formula C19H23N3O5.HCl
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 2245697-88-3
PubChem ID 134812847
Smiles NCCCCCCOC1=C2C(N(C(C2=CC=C1)=O)C3CCC(NC3=O)=O)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 40.99 100
DMF 8.2 20

Preparing Stock Solutions

The following data is based on the product molecular weight 409.86. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.44 mL 12.2 mL 24.4 mL
5 mM 0.49 mL 2.44 mL 4.88 mL
10 mM 0.24 mL 1.22 mL 2.44 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:


References are publications that support the biological activity of the product.

Nabet et al (2018) The dTAG system for immediate and target-specific protein degradation. Nat.Chem.Biol. 14 431 PMID: 29581585

Erb et al (2017) Transcription control by the ENL YEATS domain in acute leukaemia. Nature. 543 270 PMID: 28241139

If you know of a relevant reference for Thalidomide - linker 4, please let us know.

Keywords: Thalidomide - linker 4, Thalidomide - linker 4 supplier, Proteolysis, Targeting, Chimera, PROTAC, cereblon, E3, ubiquitin, ligase, conjugate, Cereblon, Ligands, Plus, Linkers, 6627, Tocris Bioscience

Citations for Thalidomide - linker 4

Citations are publications that use Tocris products.

Currently there are no citations for Thalidomide - linker 4. Do you know of a great paper that uses Thalidomide - linker 4 from Tocris? Please let us know.

Reviews for Thalidomide - linker 4

There are currently no reviews for this product. Be the first to review Thalidomide - linker 4 and earn rewards!

Have you used Thalidomide - linker 4?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Targeted Protein Degradation

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed.