Thalidomide - linker 2

Pricing Availability   Qty
Cat.No. 6468 - Thalidomide - linker 2 | C25H34N4O10.HCl
Description: Thalidomide-PEG4-ethylamine
Chemical Name: N-(14-Amino-3,6,9,12-tetraoxatetradec-1-yl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide hydrochloride
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Functionalized cereblon ligand for PROTAC research and development; incorporates an E3 ligase ligand plus a PEG linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

Technical Data

M. Wt 587.02
Formula C25H34N4O10.HCl
Storage Store at -20°C
Purity ≥95% (HPLC)
Smiles O=C(C1=C(C(OCC(NCCOCCOCCOCCOCCN)=O)=CC=C1)C2=O)N2C(C(N3)=O)CCC3=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 58.7 100
DMSO 58.7 100

Preparing Stock Solutions

The following data is based on the product molecular weight 587.02. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.7 mL 8.52 mL 17.04 mL
5 mM 0.34 mL 1.7 mL 3.41 mL
10 mM 0.17 mL 0.85 mL 1.7 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Winter et al (2015) Drug development. Phthalimide conjugation as a strategy for in vivo target protein degradation. Science 348 1376 PMID: 25999370

Salami et al (2017) Waste disposal-An attractive strategy for cancer therapy. Science 355 1163 PMID: 28302825


If you know of a relevant reference for Thalidomide - linker 2, please let us know.

View Related Products by Target

Keywords: Thalidomide - linker 2, Thalidomide - linker 2 supplier, Proteolysis, Targeting, Chimera, PROTAC, cereblon, E3, ubiquitin, ligase, PEG, linker, conjugate, polyethene, glycol, Tools, for, R&D, 6468, Tocris Bioscience

Citations for Thalidomide - linker 2

Citations are publications that use Tocris products.

Currently there are no citations for Thalidomide - linker 2. Do you know of a great paper that uses Thalidomide - linker 2 from Tocris? Please let us know.

Reviews for Thalidomide - linker 2

There are currently no reviews for this product. Be the first to review Thalidomide - linker 2 and earn rewards!

Have you used Thalidomide - linker 2?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


New Product Guide

New Product Guide (Spring/Summer 2018)

Our new product guide highlights over 200 new products added to the Tocris Bioscience range during the second half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Aptamers
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells