Thalidomide - linker 1

Pricing Availability Delivery Time Qty
Cat.No. 6467 - Thalidomide - linker 1 | C23H30N4O9.HCl
Description: Functionalized cereblon ligand for PROTACs; incorporates an E3 ligase ligand plus a PEG linker
Chemical Name: N-[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide hydrochloride
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Functionalized cereblon ligand for PROTAC research and development; incorporates an E3 ligase ligand plus a PEG linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

Technical Data

M. Wt 542.97
Formula C23H30N4O9.HCl
Storage Store at -20°C
Purity ≥95% (HPLC)
Smiles O=C(C1=C(C(OCC(NCCOCCOCCOCCN)=O)=CC=C1)C2=O)N2C(C(N3)=O)CCC3=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 54.3 100
DMSO 54.3 100

Preparing Stock Solutions

The following data is based on the product molecular weight 542.97. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.84 mL 9.21 mL 18.42 mL
5 mM 0.37 mL 1.84 mL 3.68 mL
10 mM 0.18 mL 0.92 mL 1.84 mL
50 mM 0.04 mL 0.18 mL 0.37 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Winter et al (2015) Functionalized Cereblon ligand for PROTACs; incorporates an E3 ligase ligand and a linker used in PROTAC technology. Science 348 1376 PMID: 25999370

Salami et al (2017) Waste disposal-An attractive strategy for cancer therapy. Science 355 1163 PMID: 28302825


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View Related Products by Target

Keywords: Thalidomide - linker 1, Thalidomide - linker 1 supplier, Proteolysis, Targeting, Chimera, PROTAC, cereblon, E3, ubiquitin, ligase, PEG, linker, conjugate, polyethene, glycol, Tools, for, R&D, 6467, Tocris Bioscience

Citations for Thalidomide - linker 1

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Literature in this Area

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