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Fluorescent probe for cereblon E3 ligases. Binds with high affinity to DDB1-CRBN. Suitable for use in TR-FRET.
Optical Data for Thalidomide-Cyanine 5
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 1041.2. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||4.8 mL||24.01 mL||48.02 mL|
|1 mM||0.96 mL||4.8 mL||9.6 mL|
|2 mM||0.48 mL||2.4 mL||4.8 mL|
|10 mM||0.1 mL||0.48 mL||0.96 mL|
References are publications that support the biological activity of the product.
Fischer et al (2014) Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature 512 49 PMID: 25043012
Petzold et al (2016) Structural basis of lenalidomide-induced CK1α degradation by the CRL4CRBN ubiquitin ligase. Nature 532 127 PMID: 26909574
Cavadini et al (2016) Cullin-RING ubiquitin E3 ligase regulation by the COP9 signalosome. Nature 531 598 PMID: 27029275
Chessum et al (2018) Demonstrating in-cell target engagement using a pirin protein degradation probe (CCT367766). J.Med.Chem. 61 918 PMID: 29240418
If you know of a relevant reference for Thalidomide-Cyanine 5, please let us know.
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Keywords: Thalidomide-Cyanine 5, Thalidomide-Cyanine 5 supplier, thalidomide, fluorescent, probes, time-resolved, fluorescence, resonance, energy, transfer, TR-FRET, cereblon, E3, ligases, Ubiquitin, Ligases, Enzyme, Probes, and, Substrates, 7288, Tocris Bioscience
Citations for Thalidomide-Cyanine 5
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