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Thalidomide-Cyanine 5 is a fluorescent probe for cereblon E3 ligases. Binds with high affinity to DDB1-CRBN. Suitable for use in TR-FRET.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 1041.2. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||4.8 mL||24.01 mL||48.02 mL|
|1 mM||0.96 mL||4.8 mL||9.6 mL|
|2 mM||0.48 mL||2.4 mL||4.8 mL|
|10 mM||0.1 mL||0.48 mL||0.96 mL|
References are publications that support the biological activity of the product.
Fischer et al (2014) Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature 512 49 PMID: 25043012
Petzold et al (2016) Structural basis of lenalidomide-induced CK1α degradation by the CRL4CRBN ubiquitin ligase. Nature 532 127 PMID: 26909574
Cavadini et al (2016) Cullin-RING ubiquitin E3 ligase regulation by the COP9 signalosome. Nature 531 598 PMID: 27029275
Chessum et al (2018) Demonstrating in-cell target engagement using a pirin protein degradation probe (CCT367766). J.Med.Chem. 61 918 PMID: 29240418
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Keywords: Thalidomide-Cyanine 5, Thalidomide-Cyanine 5 supplier, thalidomide, fluorescent, probes, time-resolved, fluorescence, resonance, energy, transfer, TR-FRET, cereblon, E3, ligases, Ubiquitin, Ligases, Enzyme, Probes, and, Substrates, 7288, Tocris Bioscience
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
This brochure highlights the tools and services available from Bio-Techne to support Targeted Protein Degradation research, including:
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia