Thalidomide 4'-oxyacetamide-PEG2-amine

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Description: Cereblon ligand with PEG linker and terminal amine for onward chemistry
Alternative Names: Thalidomide - linker 14
Chemical Name: N-[2-[2-(2-Aminoethoxy)ethoxy]ethyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide hydrochloride
Purity: ≥95% (HPLC)
Literature (2)

Biological Activity

Thalidomide 4'-oxyacetamide-PEG2-amine is a functionalized cereblon ligand for PROTAC® research and development; incorporates an E3 ligase ligand plus a PEG linker with ethylamine terminal ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

This product has been recently renamed. The previous name for this product was Thalidomide - linker 14

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data

M. Wt 498.92
Formula C21H26N4O8.HCl
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 2376990-30-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 24.95 50
DMF 24.95 50

Preparing Stock Solutions

The following data is based on the product molecular weight 498.92. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.01 mL 20.04 mL 40.09 mL
2.5 mM 0.8 mL 4.01 mL 8.02 mL
5 mM 0.4 mL 2 mL 4.01 mL
25 mM 0.08 mL 0.4 mL 0.8 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

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Keywords: Thalidomide 4'-oxyacetamide-PEG2-amine, Thalidomide 4'-oxyacetamide-PEG2-amine supplier, functionalized, thalidomide, E3, ligase, ligands, cereblon, PEG, linker, conjugate, PROTAC, targeted, protein, degradation, TPD, targeting, 1957235-74-3, Thalidomide, -, 14, Cereblon, Ligands, Plus, Linkers, 6967, Tocris Bioscience

Citations for Thalidomide 4'-oxyacetamide-PEG2-amine

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Literature in this Area

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Targeted Protein Degradation Research Product Guide

Targeted Protein Degradation Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support Targeted Protein Degradation research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Ubiquitin-Proteasome System Proteins
  • Assays for Protein Degradation
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia