Thalidomide 4'-ether-alkylC6-amine

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Cat.No. 6627 - Thalidomide 4'-ether-alkylC6-amine | C19H23N3O5.HCl | CAS No. 2245697-88-3
Description: Cereblon ligand with alkyl linker and terminal amine for onward chemistry
Alternative Names: Thalidomide - linker 4
Chemical Name: 4-[(6-Aminohexyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride
Purity: ≥95% (HPLC)
Reviews (1)
Literature (2)

Biological Activity

Thalidomide 4'-ether-alkylC6-amine is a functionalized cereblon ligand for PROTAC® research and development; incorporates an E3 ligase ligand plus a C6 alkyl linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTACs R&D.

This product has been recently renamed. The previous name for this product was Thalidomide - linker 4

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data

M. Wt 409.86
Formula C19H23N3O5.HCl
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 2245697-88-3
PubChem ID 134812847
Smiles NCCCCCCOC1=C2C(N(C(C2=CC=C1)=O)C3CCC(NC3=O)=O)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Nabet et al (2018) The dTAG system for immediate and target-specific protein degradation. Nat.Chem.Biol. 14 431 PMID: 29581585

Erb et al (2017) Transcription control by the ENL YEATS domain in acute leukaemia. Nature. 543 270 PMID: 28241139

If you know of a relevant reference for Thalidomide 4'-ether-alkylC6-amine, please let us know.

Keywords: Thalidomide 4'-ether-alkylC6-amine, Thalidomide 4'-ether-alkylC6-amine supplier, Proteolysis, Targeting, Chimera, PROTAC, cereblon, E3, ubiquitin, ligase, conjugate, Thalidomide, -, linker, 4, Cereblon, Ligands, Plus, Linkers, 6627, Tocris Bioscience

Citations for Thalidomide 4'-ether-alkylC6-amine

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Reviews for Thalidomide 4'-ether-alkylC6-amine

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By Anonymous on 05/20/2020
Assay Type: In Vitro
Cell Line/Tissue: A375

to make protacs

Literature in this Area

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Targeted Protein Degradation

Targeted Protein Degradation Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support Targeted Protein Degradation research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Custom Degrader Services
  • Ubiquitin-Proteasome System Proteins and Assays
  • Assays for Protein Degradation
Targeted Protein Degradation

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia