TH 1760

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Description: Potent and selective NUDT15 hydrolase inhibitor
Chemical Name: 6-[[4-(1H-Indol-5-ylcarbonyl)-1-piperazinyl]sulfonyl]-2(3H)-benzoxazolone
Purity: ≥95% (HPLC)

Biological Activity for TH 1760

TH 1760 is a potent and selective NUDT15 (nudix hydrolase 15) inhibitor (IC50 = 29 nM). Displays selectivity for NUDT15 when assayed at 100 μM against other Nudix enzymes (MTH1, NUDT2, 5, 9, 12, 14, 18, 22) and pyrophosphatases or at 10 μM when assayed with a Eurofins Cerep Safety Screen44 panel. In vitro, TH 1760 treatment sensitizes cancer cell lines (NB4 and HL-60) to thiopurine.

Technical Data for TH 1760

M. Wt 426.45
Formula C20H18N4O5S
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 2567914-01-4
PubChem ID 146048072
Smiles O=C(C1=CC=C2NC=CC2=C1)N3CCN(S(=O)(C4=CC=C5NC(OC5=C4)=O)=O)CC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TH 1760

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 4.2 10 with gentle warming

Preparing Stock Solutions for TH 1760

The following data is based on the product molecular weight 426.45. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.45 mL 117.25 mL 234.49 mL
0.5 mM 4.69 mL 23.45 mL 46.9 mL
1 mM 2.34 mL 11.72 mL 23.45 mL
5 mM 0.47 mL 2.34 mL 4.69 mL

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References for TH 1760

References are publications that support the biological activity of the product.

Zhang et al (2020) Development of a chemical probe against NUDT15. Nat.Chem.Biol. 16 1120 PMID: 32690945

If you know of a relevant reference for TH 1760, please let us know.

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Citations for TH 1760

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