Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewTH 1217
Discontinued Product
TH 1217 (Cat. No. 6522) has been withdrawn from sale for commercial reasons.
Description: Potent dCTP pyrophosphatase 1 inhibitor
Chemical Name: 2-[4-[[5,6-Dichloro-2-methyl-4-nitro-1H-benzo[d]-imidazol-1-yl]methyl]phenyl]-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione
Purity: ≥98% (HPLC)
Biological Activity for TH 1217
TH 1217 is a potent dCTPase pyrophosphatase 1 inhibitor (IC50 = 47 nM).
TH 1217 is not stable in aqueous solution. It is recommended that fresh samples are prepared and used immediately.
Licensing Information
Sold under license from Thomas Helleday's Foundation for Medical Research and Oxcia AB.
Technical Data for TH 1217
| M. Wt | 491.09 |
| Formula | C20H17BCl2N4O6 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1862212-48-3 |
| PubChem ID | 137919863 |
| InChI Key | HWFRCQHNILGMLL-UHFFFAOYSA-N |
| Smiles | CC1=NC2=C([N+]([O-])=O)C(Cl)=C(C=C2N1CC3=CC=C([B-]45OC(C[N+](CC(O5)=O)4C)=O)C=C3)Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for TH 1217
References for TH 1217
References are publications that support the biological activity of the product.
Llona-Minguez et al (2016) Discovery of the first potent and selective inhibitors of human dCTP pyrophosphatase 1. J.Med.Chem. 59 1140 PMID: 26771665
View Related Products by Target
View Related Products by Product Action
Keywords: TH 1217, TH 1217 supplier, TH1217, XTP3TPA, dCTP1, pyrophosphatase, diphosphatase, 1, inhibitors, inhibits, potent, nucleotidohydrolase, Other, Hydrolases, 6522, Tocris Bioscience
Citations for TH 1217
Citations are publications that use Tocris products.
Currently there are no citations for TH 1217.
Reviews for TH 1217
There are currently no reviews for this product. Be the first to review TH 1217 and earn rewards!
Have you used TH 1217?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image