TH 1217

Pricing Availability   Qty
Description: Potent dCTP pyrophosphatase 1 inhibitor
Chemical Name: 2-[4-[[5,6-Dichloro-2-methyl-4-nitro-1H-benzo[d]-imidazol-1-yl]methyl]phenyl]-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione
Purity: ≥98% (HPLC)

Biological Activity for TH 1217

TH 1217 is a potent dCTPase pyrophosphatase 1 inhibitor (IC50 = 47 nM).

TH 1217 is not stable in aqueous solution. It is recommended that fresh samples are prepared and used immediately.

Licensing Information

Sold under license from Thomas Helleday's Foundation for Medical Research and Oxcia AB.

Technical Data for TH 1217

M. Wt 491.09
Formula C20H17BCl2N4O6
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1862212-48-3
PubChem ID 137919863
Smiles CC1=NC2=C([N+]([O-])=O)C(Cl)=C(C=C2N1CC3=CC=C([B-]45OC(C[N+](CC(O5)=O)4C)=O)C=C3)Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TH 1217

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 49.11 100

Preparing Stock Solutions for TH 1217

The following data is based on the product molecular weight 491.09. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.04 mL 10.18 mL 20.36 mL
5 mM 0.41 mL 2.04 mL 4.07 mL
10 mM 0.2 mL 1.02 mL 2.04 mL
50 mM 0.04 mL 0.2 mL 0.41 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for TH 1217

References are publications that support the biological activity of the product.

Llona-Minguez et al (2016) Discovery of the first potent and selective inhibitors of human dCTP pyrophosphatase 1. J.Med.Chem. 59 1140 PMID: 26771665

If you know of a relevant reference for TH 1217, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Other Hydrolase Inhibitors

Keywords: TH 1217, TH 1217 supplier, TH1217, XTP3TPA, dCTP1, pyrophosphatase, diphosphatase, 1, inhibitors, inhibits, potent, nucleotidohydrolase, Other, Hydrolases, 6522, Tocris Bioscience

Citations for TH 1217

Citations are publications that use Tocris products.

Currently there are no citations for TH 1217. Do you know of a great paper that uses TH 1217 from Tocris? Please let us know.

Reviews for TH 1217

There are currently no reviews for this product. Be the first to review TH 1217 and earn rewards!

Have you used TH 1217?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review