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TH 1217

Cat. No. 6522 Submit a Review Datasheet / COA / SDS
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Description: Potent dCTP pyrophosphatase 1 inhibitor
Chemical Name: 2-[4-[[5,6-Dichloro-2-methyl-4-nitro-1H-benzo[d]-imidazol-1-yl]methyl]phenyl]-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione
Purity: ≥98% (HPLC)
Datasheet
Citations
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for TH 1217

TH 1217 is a potent dCTPase pyrophosphatase 1 inhibitor (IC50 = 47 nM).

TH 1217 is not stable in aqueous solution. It is recommended that fresh samples are prepared and used immediately.

Licensing Information

Sold under license from Thomas Helleday's Foundation for Medical Research and Oxcia AB.

Technical Data for TH 1217

M. Wt 491.09
Formula C20H17BCl2N4O6
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1862212-48-3
PubChem ID 137919863
InChI Key HWFRCQHNILGMLL-UHFFFAOYSA-N
Smiles CC1=NC2=C([N+]([O-])=O)C(Cl)=C(C=C2N1CC3=CC=C([B-]45OC(C[N+](CC(O5)=O)4C)=O)C=C3)Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TH 1217

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 49.11 100

Preparing Stock Solutions for TH 1217

The following data is based on the product molecular weight 491.09. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.04 mL 10.18 mL 20.36 mL
5 mM 0.41 mL 2.04 mL 4.07 mL
10 mM 0.2 mL 1.02 mL 2.04 mL
50 mM 0.04 mL 0.2 mL 0.41 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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References for TH 1217

References are publications that support the biological activity of the product.

Llona-Minguez et al (2016) Discovery of the first potent and selective inhibitors of human dCTP pyrophosphatase 1. J.Med.Chem. 59 1140 PMID: 26771665

If you know of a relevant reference for TH 1217, please let us know.

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Citations for TH 1217

Citations are publications that use Tocris products.

Currently there are no citations for TH 1217. Do you know of a great paper that uses TH 1217 from Tocris? Please let us know.

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