TH 1217

Discontinued Product

TH 1217 (Cat. No. 6522) has been withdrawn from sale for commercial reasons.
Description: Potent dCTP pyrophosphatase 1 inhibitor
Chemical Name: 2-[4-[[5,6-Dichloro-2-methyl-4-nitro-1H-benzo[d]-imidazol-1-yl]methyl]phenyl]-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione
Purity: ≥98% (HPLC)

Biological Activity for TH 1217

TH 1217 is a potent dCTPase pyrophosphatase 1 inhibitor (IC50 = 47 nM).

TH 1217 is not stable in aqueous solution. It is recommended that fresh samples are prepared and used immediately.

Licensing Information

Sold under license from Thomas Helleday's Foundation for Medical Research and Oxcia AB.

Technical Data for TH 1217

M. Wt 491.09
Formula C20H17BCl2N4O6
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1862212-48-3
PubChem ID 137919863
Smiles CC1=NC2=C([N+]([O-])=O)C(Cl)=C(C=C2N1CC3=CC=C([B-]45OC(C[N+](CC(O5)=O)4C)=O)C=C3)Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for TH 1217

References are publications that support the biological activity of the product.

Llona-Minguez et al (2016) Discovery of the first potent and selective inhibitors of human dCTP pyrophosphatase 1. J.Med.Chem. 59 1140 PMID: 26771665

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Citations for TH 1217

Citations are publications that use Tocris products.

Currently there are no citations for TH 1217.

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