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Biological Activity for TH 10785
TH 10785 is an 8-oxo guanine DNA glycosylase 1 (OGG1) activator. It binds in the active site of OGG1 and increases its recruitment to oxidative DNA damage and its repair.
Technical Data for TH 10785
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TH 10785
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for TH 10785
The following data is based on the product molecular weight 267.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.74 mL||18.7 mL||37.4 mL|
|5 mM||0.75 mL||3.74 mL||7.48 mL|
|10 mM||0.37 mL||1.87 mL||3.74 mL|
|50 mM||0.07 mL||0.37 mL||0.75 mL|
References for TH 10785
References are publications that support the biological activity of the product.
Michel et al (2022) Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function. Science 376 1471 PMID: 35737787
If you know of a relevant reference for TH 10785, please let us know.
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Keywords: TH 10785, TH 10785 supplier, TH10785, OGG1, 8-oxoguanine, DNA, glycosylase, activators, activates, damage, repair, Glycosylases, Enzyme, Substrates, /, Activators, 7778, Tocris Bioscience
Citations for TH 10785
Citations are publications that use Tocris products.
Currently there are no citations for TH 10785. Do you know of a great paper that uses TH 10785 from Tocris? Please let us know.
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