TH 10785

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Description: OGG1 activator
Chemical Name: N-Cyclohexyl-2-cyclopropyl-4-quinazolinamine
Purity: ≥98% (HPLC)

Biological Activity for TH 10785

TH 10785 is an 8-oxo guanine DNA glycosylase 1 (OGG1) activator. It binds in the active site of OGG1 and increases its recruitment to oxidative DNA damage and its repair.

Technical Data for TH 10785

M. Wt 267.38
Formula C17H21N3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1002801-51-5
PubChem ID 8078523
Smiles C1(N=C(C2CC2)N=C3NC4CCCCC4)=C3C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TH 10785

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 26.74 100
ethanol 26.74 100

Preparing Stock Solutions for TH 10785

The following data is based on the product molecular weight 267.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.74 mL 18.7 mL 37.4 mL
5 mM 0.75 mL 3.74 mL 7.48 mL
10 mM 0.37 mL 1.87 mL 3.74 mL
50 mM 0.07 mL 0.37 mL 0.75 mL

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References for TH 10785

References are publications that support the biological activity of the product.

Michel et al (2022) Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function. Science 376 1471 PMID: 35737787

If you know of a relevant reference for TH 10785, please let us know.

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Keywords: TH 10785, TH 10785 supplier, TH10785, OGG1, 8-oxoguanine, DNA, glycosylase, activators, activates, damage, repair, Glycosylases, Enzyme, Substrates, /, Activators, 7778, Tocris Bioscience

Citations for TH 10785

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