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TH 1020

Cat. No. 6191 Submit a Review Datasheet / COA / SDS
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Description: Toll-like receptor (TLR) 5/Flagellin complex antagonist
Chemical Name: 4-[[4-(Phenylmethyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for TH 1020

TH 1020 is a toll-like receptor (TLR) 5/Flagellin complex antagonist (IC50 = 0.85 μM). Competes with flagellin for TLR5 binding to inhibit the TLR5:flagellin interaction and subsequent downstream TNF-α secretion.

Technical Data for TH 1020

M. Wt 453.54
Formula C23H15N7S2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1841460-82-9
PubChem ID 124203921
InChI Key CBBXTGWSGPEJEE-UHFFFAOYSA-N
Smiles N1(C(SC2=C3SC4=NC=CC=C4C3=NC=N2)=NN=C1C5=CC=NC=C5)CC6=CC=CC=C6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TH 1020

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 2.27 5 with gentle warming

Preparing Stock Solutions for TH 1020

The following data is based on the product molecular weight 453.54. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 44.1 mL 220.49 mL 440.98 mL
0.25 mM 8.82 mL 44.1 mL 88.2 mL
0.5 mM 4.41 mL 22.05 mL 44.1 mL
2.5 mM 0.88 mL 4.41 mL 8.82 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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References for TH 1020

References are publications that support the biological activity of the product.

Yan et al (2016) Pyrimidine triazole thioether derivatives as toll-like receptor 5 (TLR5)/flagellin complex inhibitors. Chem.Med.Chem. 11 822 PMID: 26634412

If you know of a relevant reference for TH 1020, please let us know.

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Citations for TH 1020

Citations are publications that use Tocris products.

Currently there are no citations for TH 1020. Do you know of a great paper that uses TH 1020 from Tocris? Please let us know.

Reviews for TH 1020

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Literature in this Area

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Pathways for TH 1020

Toll-like Receptor Signaling Pathway

Toll-like Receptor Signaling Pathway

TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.