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Biological Activity for TH 1020
TH 1020 is a toll-like receptor (TLR) 5/Flagellin complex antagonist (IC50 = 0.85 μM). Competes with flagellin for TLR5 binding to inhibit the TLR5:flagellin interaction and subsequent downstream TNF-α secretion.
Technical Data for TH 1020
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References for TH 1020
References are publications that support the biological activity of the product.
Yan et al (2016) Pyrimidine triazole thioether derivatives as toll-like receptor 5 (TLR5)/flagellin complex inhibitors. Chem.Med.Chem. 11 822 PMID: 26634412
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Keywords: TH 1020, TH 1020 supplier, TH1020, Toll, like, receptor, flagellin, complex, TLR5, TNFalpha, TNFa, TNFα, Toll-like, Receptors, 6191, Tocris Bioscience
Citations for TH 1020
Citations are publications that use Tocris products.
Currently there are no citations for TH 1020.
Reviews for TH 1020
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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