TH 1020

Discontinued Product

TH 1020 (Cat. No. 6191) has been withdrawn from sale for commercial reasons.
Description: Toll-like receptor (TLR) 5/Flagellin complex antagonist
Chemical Name: 4-[[4-(Phenylmethyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine
Purity: ≥98% (HPLC)
Pathways (1)

Biological Activity for TH 1020

TH 1020 is a toll-like receptor (TLR) 5/Flagellin complex antagonist (IC50 = 0.85 μM). Competes with flagellin for TLR5 binding to inhibit the TLR5:flagellin interaction and subsequent downstream TNF-α secretion.

Technical Data for TH 1020

M. Wt 453.54
Formula C23H15N7S2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1841460-82-9
PubChem ID 124203921
Smiles N1(C(SC2=C3SC4=NC=CC=C4C3=NC=N2)=NN=C1C5=CC=NC=C5)CC6=CC=CC=C6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for TH 1020

References are publications that support the biological activity of the product.

Yan et al (2016) Pyrimidine triazole thioether derivatives as toll-like receptor 5 (TLR5)/flagellin complex inhibitors. Chem.Med.Chem. 11 822 PMID: 26634412

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Keywords: TH 1020, TH 1020 supplier, TH1020, Toll, like, receptor, flagellin, complex, TLR5, TNFalpha, TNFa, TNFα, Toll-like, Receptors, 6191, Tocris Bioscience

Citations for TH 1020

Citations are publications that use Tocris products.

Currently there are no citations for TH 1020.

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Pathways for TH 1020

Toll-like Receptor Signaling Pathway

Toll-like Receptor Signaling Pathway

TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.