TH 1020

Pricing Availability Delivery Time Qty
Cat.No. 6191 - TH 1020 | C23H15N7S2 | CAS No. 1841460-82-9
Description: Toll-like receptor (TLR) 5/Flagellin complex antagonist
Chemical Name: 4-[[4-(Phenylmethyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature
Pathways

Biological Activity

Toll-like receptor (TLR) 5/Flagellin complex antagonist (IC50 = 0.85 μM). Competes with flagellin for TLR5 binding to inhibit the TLR5:flagellin interaction and subsequent downstream TNF-α secretion.

Technical Data

M. Wt 453.54
Formula C23H15N7S2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1841460-82-9
PubChem ID 124203921
InChI Key CBBXTGWSGPEJEE-UHFFFAOYSA-N
Smiles N1(C(SC2=C3SC4=NC=CC=C4C3=NC=N2)=NN=C1C5=CC=NC=C5)CC6=CC=CC=C6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 2.27 5mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 453.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.2 mL 11.02 mL 22.05 mL
5 mM 0.44 mL 2.2 mL 4.41 mL
10 mM 0.22 mL 1.1 mL 2.2 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Yan et al (2016) Pyrimidine triazole thioether derivatives as toll-like receptor 5 (TLR5)/flagellin complex inhibitors. Chem.Med.Chem. 11 822 PMID: 26634412


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Keywords: TH 1020, supplier, TH1020, Toll, like, receptor, flagellin, complex, TLR5, TNFalpha, TNFa, TNFα, Toll-like, Receptors, Toll-like, Receptors, Tocris Bioscience

Citations for TH 1020

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Pathways for TH 1020

Toll-like Receptor

Toll-like Receptor Signaling Pathway

TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.