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Biological Activity for TH 1020
TH 1020 is a toll-like receptor (TLR) 5/Flagellin complex antagonist (IC50 = 0.85 μM). Competes with flagellin for TLR5 binding to inhibit the TLR5:flagellin interaction and subsequent downstream TNF-α secretion.
Technical Data for TH 1020
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TH 1020
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||2.27||5 with gentle warming|
Preparing Stock Solutions for TH 1020
The following data is based on the product molecular weight 453.54. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.05 mM||44.1 mL||220.49 mL||440.98 mL|
|0.25 mM||8.82 mL||44.1 mL||88.2 mL|
|0.5 mM||4.41 mL||22.05 mL||44.1 mL|
|2.5 mM||0.88 mL||4.41 mL||8.82 mL|
References for TH 1020
References are publications that support the biological activity of the product.
Yan et al (2016) Pyrimidine triazole thioether derivatives as toll-like receptor 5 (TLR5)/flagellin complex inhibitors. Chem.Med.Chem. 11 822 PMID: 26634412
If you know of a relevant reference for TH 1020, please let us know.
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Keywords: TH 1020, TH 1020 supplier, TH1020, Toll, like, receptor, flagellin, complex, TLR5, TNFalpha, TNFa, TNFα, Toll-like, Receptors, 6191, Tocris Bioscience
Citations for TH 1020
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Reviews for TH 1020
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Literature in this Area
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