TFLLR-NH2

Pricing Availability   Qty
Cat.No. 1464 - TFLLR-NH2 | Thr-Phe-Leu-Leu-Arg-NH2 | CAS No. 197794-83-5
Description: PAR1-activating peptide
Datasheet
Citations (11)
Reviews (1)
Literature (3)

Biological Activity

Peptide derived from the protease-activated receptor-1 (PAR1) that acts as a PAR1 selective agonist (EC50 = 1.9 μM). Stimulates PAR1-mediated plasma extravasation in vivo.

Control Peptide also available.

Technical Data

M. Wt 647.82
Formula C31H53N9O6
Sequence TFLLR

(Modifications: Arg-5 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 197794-83-5
PubChem ID 10146183
InChI Key ANAMCEKSRDPIPX-GFGQVAFXSA-N
Smiles [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

de Garavilla et al (2001) Agonists of proteinase-activated receptor 1 induce plasma extravasation by a neurogenic mechanism. Br.J.Pharmacol. 133 975 PMID: 11487506

Hollenberg et al (1997) Proteinase-activated receptors: structural requirements for activity, receptor cross-reactivity, and receptor selectivity of receptor-activating peptides. Can.J.Physiol.Pharmacol. 75 832 PMID: 9315351

Kawabata et al (2000) Characterization of the protease-activated receptor-1-mediated contraction and relaxation in the rat duodenal smooth muscle. Life Sci. 67 2521 PMID: 11065174


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Keywords: TFLLR-NH2, TFLLR-NH2 supplier, PAR1-activating, peptide, PAR, Receptors, Protease-Activated, proteinase-activated, 1464, Tocris Bioscience

11 Citations for TFLLR-NH2

Citations are publications that use Tocris products. Selected citations for TFLLR-NH2 include:

Chen et al (2012) Thrombin activity associated with neuronal damage during acute focal ischemia. J Neurosci 32 7622 PMID: 22649241

Zhang et al (2017) PAR1?mediated c?Jun activation promotes heat stress?induced early stage apoptosis of human umbilical vein endothelial cells. Mol Med Rep 15 2595 PMID: 28447716

Vellani et al (2010) Protease activated receptors 1 and 4 sensitize TRPV1 in nociceptive neurones. Mol Pain 6 61 PMID: 20875131

Fujimoto et al (2010) The activation of Proteinase-Activated Receptor-1 (PAR1) mediates gastric cancer cell proliferation and invasion. BMC Cancer 10 443 PMID: 20723226


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Reviews for TFLLR-NH2

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Effect of TFLLR-NH2 on TGFb1 release by platelets.
By Anonymous on 12/16/2018
Assay Type: Ex Vivo
Species: Human

5uM TFLLR-NH2 was treated on platelets and the TGFb1 release was measured by ELISA.


Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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