Pricing Availability   Qty
Cat.No. 1464 - TFLLR-NH2 | Thr-Phe-Leu-Leu-Arg-NH2 | CAS No. 197794-83-5
Description: PAR1-activating peptide
Citations (11)
Reviews (2)
Literature (3)

Biological Activity for TFLLR-NH2

TFLLR-NH2 is a peptide derived from the protease-activated receptor-1 (PAR1) that acts as a PAR1 selective agonist (EC50 = 1.9 μM). Stimulates PAR1-mediated plasma extravasation in vivo.

Control Peptide also available.

Technical Data for TFLLR-NH2

M. Wt 647.82
Formula C31H53N9O6
Sequence TFLLR

(Modifications: Arg-5 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 197794-83-5
PubChem ID 10146183
Smiles [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TFLLR-NH2

Solubility Soluble to 1 mg/ml in water

Product Datasheets for TFLLR-NH2

Certificate of Analysis / Product Datasheet
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References for TFLLR-NH2

References are publications that support the biological activity of the product.

de Garavilla et al (2001) Agonists of proteinase-activated receptor 1 induce plasma extravasation by a neurogenic mechanism. Br.J.Pharmacol. 133 975 PMID: 11487506

Hollenberg et al (1997) Proteinase-activated receptors: structural requirements for activity, receptor cross-reactivity, and receptor selectivity of receptor-activating peptides. Can.J.Physiol.Pharmacol. 75 832 PMID: 9315351

Kawabata et al (2000) Characterization of the protease-activated receptor-1-mediated contraction and relaxation in the rat duodenal smooth muscle. Life Sci. 67 2521 PMID: 11065174

If you know of a relevant reference for TFLLR-NH2, please let us know.

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Keywords: TFLLR-NH2, TFLLR-NH2 supplier, PAR1-activating, peptide, PAR, Receptors, Protease-Activated, proteinase-activated, 1464, Tocris Bioscience

11 Citations for TFLLR-NH2

Citations are publications that use Tocris products. Selected citations for TFLLR-NH2 include:

Chen et al (2012) Thrombin activity associated with neuronal damage during acute focal ischemia. J Neurosci 32 7622 PMID: 22649241

Vellani et al (2010) Protease activated receptors 1 and 4 sensitize TRPV1 in nociceptive neurones. Mol Pain 6 61 PMID: 20875131

Fujimoto et al (2010) The activation of Proteinase-Activated Receptor-1 (PAR1) mediates gastric cancer cell proliferation and invasion. BMC Cancer 10 443 PMID: 20723226

Gómez-Gonzalo et al (2010) An excitatory loop with astrocytes contributes to drive neurons to seizure threshold. PLoS Biol 8 e1000352 PMID: 20405049

Do you know of a great paper that uses TFLLR-NH2 from Tocris? Please let us know.

Reviews for TFLLR-NH2

Average Rating: 5 (Based on 2 Reviews.)

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Effect of TFLLR-NH2 on PLCbeta activity in HASMCs.
By Anonymous on 04/06/2021
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: HASM cell

Effect of TFLLR-NH2 on PLCbeta activity in HASMCs

Effect of TFLLR-NH2 on TGFb1 release by platelets.
By Anonymous on 12/16/2018
Assay Type: Ex Vivo
Species: Human

5uM TFLLR-NH2 was treated on platelets and the TGFb1 release was measured by ELISA.

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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