TFLLR-NH2

Pricing Availability   Qty

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Description: PAR1-activating peptide
Purity: ≥95% (HPLC)
Datasheet
Citations (11)
Reviews
Literature (3)

Biological Activity for TFLLR-NH2

TFLLR-NH2 is a peptide derived from the protease-activated receptor-1 (PAR1) that acts as a PAR1 selective agonist (EC50 = 1.9 μM). Stimulates PAR1-mediated plasma extravasation in vivo.

Control Peptide also available.

Technical Data for TFLLR-NH2

M. Wt 647.82
Formula C31H53N9O6
Sequence TFLLR

(Modification: Arg-5 = C-terminal amide)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 197794-83-5
PubChem ID 10146183
InChI Key ANAMCEKSRDPIPX-GFGQVAFXSA-N
Smiles [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TFLLR-NH2

Solubility Soluble to 1 mg/ml in water

Product Datasheets for TFLLR-NH2

Certificate of Analysis / Product Datasheet
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References for TFLLR-NH2

References are publications that support the biological activity of the product.

de Garavilla et al (2001) Agonists of proteinase-activated receptor 1 induce plasma extravasation by a neurogenic mechanism. Br.J.Pharmacol. 133 975 PMID: 11487506

Hollenberg et al (1997) Proteinase-activated receptors: structural requirements for activity, receptor cross-reactivity, and receptor selectivity of receptor-activating peptides. Can.J.Physiol.Pharmacol. 75 832 PMID: 9315351

Kawabata et al (2000) Characterization of the protease-activated receptor-1-mediated contraction and relaxation in the rat duodenal smooth muscle. Life Sci. 67 2521 PMID: 11065174


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Keywords: TFLLR-NH2, TFLLR-NH2 supplier, PAR1-activating, peptide, PAR, Receptors, Protease-Activated, proteinase-activated, 1464, Tocris Bioscience

11 Citations for TFLLR-NH2

Citations are publications that use Tocris products. Selected citations for TFLLR-NH2 include:

Chen et al (2012) Thrombin activity associated with neuronal damage during acute focal ischemia. J Neurosci 32 7622 PMID: 22649241

Vellani et al (2010) Protease activated receptors 1 and 4 sensitize TRPV1 in nociceptive neurones. Mol Pain 6 61 PMID: 20875131

Fujimoto et al (2010) The activation of Proteinase-Activated Receptor-1 (PAR1) mediates gastric cancer cell proliferation and invasion. BMC Cancer 10 443 PMID: 20723226

Gómez-Gonzalo et al (2010) An excitatory loop with astrocytes contributes to drive neurons to seizure threshold. PLoS Biol 8 e1000352 PMID: 20405049


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Reviews for TFLLR-NH2

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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