Pricing Availability   Qty
Description: PAR1-activating peptide
Purity: ≥95% (HPLC)
Citations (11)

Biological Activity for TFLLR-NH2

TFLLR-NH2 is a peptide derived from the protease-activated receptor-1 (PAR1) that acts as a PAR1 selective agonist (EC50 = 1.9 μM). Stimulates PAR1-mediated plasma extravasation in vivo.

Control Peptide also available.

Technical Data for TFLLR-NH2

M. Wt 647.82
Formula C31H53N9O6
Sequence TFLLR

(Modification: Arg-5 = C-terminal amide)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 197794-83-5
PubChem ID 10146183
Smiles [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TFLLR-NH2

Solubility Soluble to 1 mg/ml in water

Product Datasheets for TFLLR-NH2

Certificate of Analysis / Product Datasheet
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References for TFLLR-NH2

References are publications that support the biological activity of the product.

de Garavilla et al (2001) Agonists of proteinase-activated receptor 1 induce plasma extravasation by a neurogenic mechanism. Br.J.Pharmacol. 133 975 PMID: 11487506

Hollenberg et al (1997) Proteinase-activated receptors: structural requirements for activity, receptor cross-reactivity, and receptor selectivity of receptor-activating peptides. Can.J.Physiol.Pharmacol. 75 832 PMID: 9315351

Kawabata et al (2000) Characterization of the protease-activated receptor-1-mediated contraction and relaxation in the rat duodenal smooth muscle. Life Sci. 67 2521 PMID: 11065174

If you know of a relevant reference for TFLLR-NH2, please let us know.

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Keywords: TFLLR-NH2, TFLLR-NH2 supplier, PAR1-activating, peptide, PAR, Receptors, Protease-Activated, proteinase-activated, 1464, Tocris Bioscience

11 Citations for TFLLR-NH2

Citations are publications that use Tocris products. Selected citations for TFLLR-NH2 include:

Müller et al (2018) Effective Glucose Uptake by Human Astrocytes Requires Its Sequestration in the Endoplasmic Reticulum by Glucose-6-Phosphatase-β. Curr Biol 28 3481 PMID: 30415704

Zhang et al (2019) Selectively activated PRP exerts differential effects on tendon stem/progenitor cells and tendon healing. J Tissue Eng 10 2041731418820030 PMID: 30728936

Wang (2017) Complement-activation fragment C4a mediates effector functions by binding as untethered agonist to protease-activated receptors 1 and 4. Proc Natl Acad Sci U S A 114 10948 PMID: 28973891

Zhang et al (2017) PAR1?mediated c?Jun activation promotes heat stress?induced early stage apoptosis of human umbilical vein endothelial cells. Mol Med Rep 15 2595 PMID: 28447716

Do you know of a great paper that uses TFLLR-NH2 from Tocris? Please let us know.

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