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Biological Activity for TFLLR-NH2
TFLLR-NH2 is a peptide derived from the protease-activated receptor-1 (PAR1) that acts as a PAR1 selective agonist (EC50 = 1.9 μM). Stimulates PAR1-mediated plasma extravasation in vivo.
Control Peptide also available.
Technical Data for TFLLR-NH2
(Modifications: Arg-5 = C-terminal amide)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TFLLR-NH2
|Solubility||Soluble to 1 mg/ml in water|
References for TFLLR-NH2
References are publications that support the biological activity of the product.
de Garavilla et al (2001) Agonists of proteinase-activated receptor 1 induce plasma extravasation by a neurogenic mechanism. Br.J.Pharmacol. 133 975 PMID: 11487506
Hollenberg et al (1997) Proteinase-activated receptors: structural requirements for activity, receptor cross-reactivity, and receptor selectivity of receptor-activating peptides. Can.J.Physiol.Pharmacol. 75 832 PMID: 9315351
Kawabata et al (2000) Characterization of the protease-activated receptor-1-mediated contraction and relaxation in the rat duodenal smooth muscle. Life Sci. 67 2521 PMID: 11065174
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Keywords: TFLLR-NH2, TFLLR-NH2 supplier, PAR1-activating, peptide, PAR, Receptors, Protease-Activated, proteinase-activated, 1464, Tocris Bioscience
11 Citations for TFLLR-NH2
Citations are publications that use Tocris products. Selected citations for TFLLR-NH2 include:
Chen et al (2012) Thrombin activity associated with neuronal damage during acute focal ischemia. J Neurosci 32 7622 PMID: 22649241
Vellani et al (2010) Protease activated receptors 1 and 4 sensitize TRPV1 in nociceptive neurones. Mol Pain 6 61 PMID: 20875131
Fujimoto et al (2010) The activation of Proteinase-Activated Receptor-1 (PAR1) mediates gastric cancer cell proliferation and invasion. BMC Cancer 10 443 PMID: 20723226
Gómez-Gonzalo et al (2010) An excitatory loop with astrocytes contributes to drive neurons to seizure threshold. PLoS Biol 8 e1000352 PMID: 20405049
Müller et al (2018) Effective Glucose Uptake by Human Astrocytes Requires Its Sequestration in the Endoplasmic Reticulum by Glucose-6-Phosphatase-β. Curr Biol 28 3481 PMID: 30415704
Zhang et al (2017) PAR1?mediated c?Jun activation promotes heat stress?induced early stage apoptosis of human umbilical vein endothelial cells. Mol Med Rep 15 2595 PMID: 28447716
Carlsen and Perrier (2014) Purines released from astrocytes inhibit excitatory synaptic transmission in the ventral horn of the spinal cord. Front Neural Circuits 8 60 PMID: 24926236
Wang (2017) Complement-activation fragment C4a mediates effector functions by binding as untethered agonist to protease-activated receptors 1 and 4. Proc Natl Acad Sci U S A 114 10948 PMID: 28973891
Wang et al (2012) Astrocytes modulate neural network activity by Ca2+-dependent uptake of extracellular K+. J Neuroinflammation 5 ra26 PMID: 22472648
Chen et al (2012) Transient early neurotrophin release and delayed inflammatory cytokine release by microglia in response to PAR-2 stimulation. Endocrinology 9 142 PMID: 22731117
Zhang et al (2019) Selectively activated PRP exerts differential effects on tendon stem/progenitor cells and tendon healing. J Tissue Eng 10 2041731418820030 PMID: 30728936
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Reviews for TFLLR-NH2
Average Rating: 5 (Based on 2 Reviews.)
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Effect of TFLLR-NH2 on PLCbeta activity in HASMCs
5uM TFLLR-NH2 was treated on platelets and the TGFb1 release was measured by ELISA.
Literature in this Area
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