TFLLR-NH2

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Cat.No. 1464 - TFLLR-NH2 | Thr-Phe-Leu-Leu-Arg-NH2 | CAS No. 197794-83-5
Description: PAR1-activating peptide
Datasheet
Citations (7)
Literature

Biological Activity

Peptide derived from the protease-activated receptor-1 (PAR1) that acts as a PAR1 selective agonist (EC50 = 1.9 μM). Stimulates PAR1-mediated plasma extravasation in vivo. Control Peptide RLLFT-NH2 (Cat. No. 3393) also available.

Technical Data

M. Wt 647.82
Formula C31H53N9O6
Sequence TFLLR

(Modifications: Arg-5 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 197794-83-5
PubChem ID 10146183
InChI Key ANAMCEKSRDPIPX-GFGQVAFXSA-N
Smiles [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 647.82. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.54 mL 7.72 mL 15.44 mL
5 mM 0.31 mL 1.54 mL 3.09 mL
10 mM 0.15 mL 0.77 mL 1.54 mL
50 mM 0.03 mL 0.15 mL 0.31 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

de Garavilla et al (2001) Agonists of proteinase-activated receptor 1 induce plasma extravasation by a neurogenic mechanism. Br.J.Pharmacol. 133 975 PMID: 11487506

Hollenberg et al (1997) Proteinase-activated receptors: structural requirements for activity, receptor cross-reactivity, and receptor selectivity of receptor-activating peptides. Can.J.Physiol.Pharmacol. 75 832 PMID: 9315351

Kawabata et al (2000) Characterization of the protease-activated receptor-1-mediated contraction and relaxation in the rat duodenal smooth muscle. Life Sci. 67 2521 PMID: 11065174


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Keywords: TFLLR-NH2, supplier, PAR1-activating, peptide, PAR, Receptors, Protease-Activated, proteinase-activated, Protease-Activated, Receptors, Tocris Bioscience

7 Citations for TFLLR-NH2

Citations are publications that use Tocris products. Selected citations for TFLLR-NH2 include:

Carlsen and Perrier (2014) Purines released from astrocytes inhibit excitatory synaptic transmission in the ventral horn of the spinal cord. Front Neural Circuits 8 60 PMID: 24926236

Chen et al (2012) Thrombin activity associated with neuronal damage during acute focal ischemia. J Neurosci 32 7622 PMID: 22649241

Wang et al (2012) Astrocytes modulate neural network activity by Ca2+-dependent uptake of extracellular K+. J Neuroinflammation 5 ra26 PMID: 22472648

Chen et al (2012) Transient early neurotrophin release and delayed inflammatory cytokine release by microglia in response to PAR-2 stimulation. Endocrinology 9 142 PMID: 22731117

Vellani et al (2010) Protease activated receptors 1 and 4 sensitize TRPV1 in nociceptive neurones. Mol Pain 6 61 PMID: 20875131

Fujimoto et al (2010) The activation of Proteinase-Activated Receptor-1 (PAR1) mediates gastric cancer cell proliferation and invasion. BMC Cancer 10 443 PMID: 20723226

Gómez-Gonzalo et al (2010) An excitatory loop with astrocytes contributes to drive neurons to seizure threshold. PLoS Biol 8 e1000352 PMID: 20405049


Do you know of a great paper that uses TFLLR-NH2 from Tocris? If so please let us know.

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Pathways for TFLLR-NH2

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