RLLFT-NH2

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Cat.No. 3393 - RLLFT-NH2 | Arg-Leru-Leu-Phe-Thr-NH2 | CAS No. 447408-68-6
Description: Control peptide for TFLLR-NH2 (Cat. No. 1464)
Datasheet
Citations (1)
Literature

Biological Activity

Reversed amino acid sequence control peptide for TFLLR-NH2 (Cat. No. 1464), a PAR1 selective agonist that significantly increases nociceptive threshold.

Technical Data

M. Wt 647.82
Formula C31H53N9O6
Sequence RLLFT

(Modifications: Thr-5 = C-terminal amide)

Storage Store at -20°C
CAS Number 447408-68-6
PubChem ID 56972203
InChI Key ILPOBMZRIPLMBB-GFGQVAFXSA-N
Smiles [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 2 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 647.82. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.54 mL 7.72 mL 15.44 mL
5 mM 0.31 mL 1.54 mL 3.09 mL
10 mM 0.15 mL 0.77 mL 1.54 mL
50 mM 0.03 mL 0.15 mL 0.31 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Asfaha et al (2002) Proteinase-activated receptor-1 agonists attenuate nociception in response to noxious stimuli. Br.J.Pharmacol. 135 1101 PMID: 11877315

Fang et al (2003) Thrombin inhibits NMDA-mediated nociceptive activity in the mouse: possible mediation by endothelin. J.Physiol. 549 903 PMID: 12717003

Buresi et al (2004) Activation of proteinase-activated receptor-1 inhibits neurally evoked chloride secretion in the mouse colon in vitro. Am.J.Physiol.Gastrointest.Liver Physiol. 288 G337 PMID: 15345469


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Keywords: Control peptide TFLLR-NH2 PAR Receptors Protease-Activated proteinase-activated Protease-Activated Receptors

1 Citation for RLLFT-NH2

Citations are publications that use Tocris products. Selected citations for RLLFT-NH2 include:

Chen et al (2012) Thrombin activity associated with neuronal damage during acute focal ischemia. J Neurosci 32 7622 PMID: 22649241


Do you know of a great paper that uses RLLFT-NH2 from Tocris? If so please let us know.

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Pathways for RLLFT-NH2

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