TCS PIM-1 4a

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Cat.No. 3714 - TCS PIM-1 4a | C11H6F3NO2S | CAS No. 438190-29-5
Description: Selective, ATP-competitive Pim kinase inhibitor
Alternative Names: SMI-4a
Chemical Name: (5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective, ATP-competitive Pim kinase inhibitor (IC50 values are 24 and 100 nM for Pim-1 and Pim-2 respectively). Displays selectivity over a panel of ~50 other kinases tested. Exhibits cytotoxicity in PC3 prostate carcinoma cells in vitro (IC50 = 17 μM).

Technical Data

M. Wt 273.23
Formula C11H6F3NO2S
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 438190-29-5
PubChem ID 1361334
InChI Key NGJLOFCOEOHFKQ-YVMONPNESA-N
Smiles O=C(/C(S2)=C/C1=CC(C(F)(F)F)=CC=C1)NC2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 27.32 100
ethanol 27.32 100

Preparing Stock Solutions

The following data is based on the product molecular weight 273.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.66 mL 18.3 mL 36.6 mL
5 mM 0.73 mL 3.66 mL 7.32 mL
10 mM 0.37 mL 1.83 mL 3.66 mL
50 mM 0.07 mL 0.37 mL 0.73 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

Xia et al (2009) Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases. J.Med.Chem. 52 74 PMID: 19072652


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Keywords: TCSPIM14a pim-1 pim-2 kinases inhibitors inhibits selective ATP-competitive SMI-4a SMI-4a Pim Kinase

Citations for TCS PIM-1 4a

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases

Pathways for TCS PIM-1 4a

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