Discontinued Product

TCS HDAC6 20b (Cat. No. 4805) has been withdrawn from sale for commercial reasons.
Description: Selective HDAC6 inhibitor
Chemical Name: 2-Methylpropanethioic acid-S-[(6S)-6-[[(1,1-dimethylethoxy)carbonyl]amino]-7-oxo-7-(tricyclo[,7]dec-1-ylamino)heptyl] ester
Purity: ≥98% (HPLC)
Citations (1)
Literature (5)

Biological Activity for TCS HDAC6 20b

TCS HDAC6 20b is a selective inhibitor of histone deacetylase 6 (HDAC6). Inhibits HCT116 growth in combination with taxol (Cat. No. 1097). Also inhibits growth of MCF-7 cells stimulated by estrogen.

Technical Data for TCS HDAC6 20b

M. Wt 480.7
Formula C26H44N2O4S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 956154-63-5
PubChem ID 23636017
Smiles O=C([C@@H](NC(OC(C)(C)C)=O)CCCCCSC(C(C)C)=O)NC1(CC3C2)CC(C3)CC2C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for TCS HDAC6 20b

Certificate of Analysis / Product Datasheet
Select another batch:

References for TCS HDAC6 20b

References are publications that support the biological activity of the product.

Itoh et al (2007) Design, synthesis, structure-selectivity relationship, and effect on human cancer cells of a novel series of histone deacetylase 6-selective inhibitors. J.Med.Chem. 50 5425 PMID: 17929798

View Related Products by Product Action

View all Class II HDAC Inhibitors

Keywords: TCS HDAC6 20b, TCS HDAC6 20b supplier, TCSHDAC620b, histone, deacetylase, 6, HDAC6, inhibitors, inhibits, selective, Class, II, HDACs, 4805, Tocris Bioscience

1 Citation for TCS HDAC6 20b

Citations are publications that use Tocris products. Selected citations for TCS HDAC6 20b include:

Xiaojun et al (2016) Acetylated α-Tubulin Regulated by N-Acetyl-Seryl-Aspartyl-Lysyl-Proline(Ac-SDKP) Exerts the Anti-fibrotic Effect in Rat Lung Fibrosis Induced by Silica. Sci Rep 6 32257 PMID: 27577858

Reviews for TCS HDAC6 20b

There are currently no reviews for this product. Be the first to review TCS HDAC6 20b and earn rewards!

Have you used TCS HDAC6 20b?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer Research Product Guide

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Epigenetics Scientific Review

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

Cell Cycle & DNA Damage Repair Poster

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Epigenetics in Cancer Poster

Epigenetics in Cancer Poster

This poster summarizes the main epigenetic targets in cancer. The dysregulation of epigenetic modifications has been shown to result in oncogenesis and cancer progression. Unlike genetic mutations, epigenetic alterations are considered to be reversible and thus make promising therapeutic targets.

Rheumatoid Arthritis Poster

Rheumatoid Arthritis Poster

Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.