TCS 3035

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Description: GPR35 agonist
Chemical Name: 2-[4-[(Z)-(2,4-Dioxo-5-thiazolidinylidene)methyl]phenoxyacetic acid
Purity: ≥98% (HPLC)

Biological Activity for TCS 3035

TCS 3035 is a GPR35 agonist (pEC50 values are 5.13 and 5.86 for rat and human GPR35 orthologs, respectively).

Technical Data for TCS 3035

M. Wt 279.27
Formula C12H9NO5S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 871085-49-3
PubChem ID 2295463
Smiles O=C(/C(S2)=C/C1=CC=C(OCC(O)=O)C=C1)NC2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TCS 3035

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 27.93 100

Preparing Stock Solutions for TCS 3035

The following data is based on the product molecular weight 279.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.58 mL 17.9 mL 35.81 mL
5 mM 0.72 mL 3.58 mL 7.16 mL
10 mM 0.36 mL 1.79 mL 3.58 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

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References for TCS 3035

References are publications that support the biological activity of the product.

Jenkins et al (2011) Agonist activation of the G protein-coupled receptor GPR35 involves transmembrane domain III and is transduced via Gα13 and β-arrestin-2. Br.J.Pharmacol. 162 733 PMID: 20958291

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Keywords: TCS 3035, TCS 3035 supplier, TCS3035, GPR35, G-protein, coupled, receptors, agonists, 4244, Tocris Bioscience

Citations for TCS 3035

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