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Biological Activity for TCPOBOP
TCPOBOP is an agonist of the constitutive androstane receptor (CAR) (EC50 = 20 nM). Induces activity of ER1 cytochrome P450 isozymes, NADPH-cytochrome c reductase, microsomal epoxide hydrolase and glutathione S transferase. Potent mitogen; induces liver cell proliferation in mice.
Technical Data for TCPOBOP
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References for TCPOBOP
References are publications that support the biological activity of the product.
Ledda-Columbano et al (1998) In vivo hepatocyte proliferation is inducible through a TNF and IL-6-independent pathway. Oncogene 17 1039 PMID: 9747883
Poland et al (1980) 1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene, a potent phenobarbital-like inducer of microsomal monooxygenase activity. Mol.Pharmacol. 18 571 PMID: 7464820
Tzameli et al (2000) The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR. Mol.Cell.Biol. 20 2951 PMID: 10757780
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Keywords: TCPOBOP, TCPOBOP supplier, agonists, nuclear, receptor, CAR, constitutive, androstane, receptors, mitogens, mitogenic, Constitutive, Androstane, Receptor, 1225, Tocris Bioscience
Citations for TCPOBOP
Citations are publications that use Tocris products.
Currently there are no citations for TCPOBOP.
Reviews for TCPOBOP
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Literature in this Area
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