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Agonist of the constitutive androstane receptor (CAR) (EC50 = 20 nM). Induces activity of ER1 cytochrome P450 isozymes, NADPH-cytochrome c reductase, microsomal epoxide hydrolase and glutathione S transferase. Potent mitogen; induces liver cell proliferation in mice.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 402.06. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||24.87 mL||124.36 mL||248.72 mL|
|0.5 mM||4.97 mL||24.87 mL||49.74 mL|
|1 mM||2.49 mL||12.44 mL||24.87 mL|
|5 mM||0.5 mL||2.49 mL||4.97 mL|
References are publications that support the biological activity of the product.
Ledda-Columbano et al (1998) In vivo hepatocyte proliferation is inducible through a TNF and IL-6-independent pathway. Oncogene 17 1039 PMID: 9747883
Poland et al (1980) 1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene, a potent phenobarbital-like inducer of microsomal monooxygenase activity. Mol.Pharmacol. 18 571 PMID: 7464820
Tzameli et al (2000) The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR. Mol.Cell.Biol. 20 2951 PMID: 10757780
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Keywords: TCPOBOP, TCPOBOP supplier, agonists, nuclear, receptor, CAR, constitutive, androstane, receptors, mitogens, mitogenic, Constitutive, Androstane, Receptor, 1225, Tocris Bioscience
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