TCPOBOP

Pricing Availability Delivery Time Qty
Cat.No. 1225 - TCPOBOP | C16H8Cl4N2O2 | CAS No. 76150-91-9
Description: Constitutive androstane receptor agonist
Chemical Name: 1,4-Bis(3,5-Dichloro-2-pyridinyloxy)benzene
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Agonist of the constitutive androstane receptor (CAR) (EC50 = 20 nM). Induces activity of ER1 cytochrome P450 isozymes, NADPH-cytochrome c reductase, microsomal epoxide hydrolase and glutathione S transferase. Potent mitogen; induces liver cell proliferation in mice.

Technical Data

M. Wt 402.06
Formula C16H8Cl4N2O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 76150-91-9
PubChem ID 5382
InChI Key BAFKRPOFIYPKBQ-UHFFFAOYSA-N
Smiles ClC(C=N3)=CC(Cl)=C3OC(C=C2)=CC=C2OC1=NC=C(Cl)C=C1Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.02 10

Preparing Stock Solutions

The following data is based on the product molecular weight 402.06. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.49 mL 12.44 mL 24.87 mL
5 mM 0.5 mL 2.49 mL 4.97 mL
10 mM 0.25 mL 1.24 mL 2.49 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Ledda-Columbano et al (1998) In vivo hepatocyte proliferation is inducible through a TNF and IL-6-independent pathway. Oncogene 17 1039 PMID: 9747883

Poland et al (1980) 1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene, a potent phenobarbital-like inducer of microsomal monooxygenase activity. Mol.Pharmacol. 18 571 PMID: 7464820

Tzameli et al (2000) The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR. Mol.Cell.Biol. 20 2951 PMID: 10757780


If you know of a relevant reference for TCPOBOP, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Constitutive Androstane Receptor Agonists

Keywords: agonists nuclear receptor CAR constitutive androstane receptors mitogens mitogenic Constitutive Androstane Receptor

Citations for TCPOBOP

Citations are publications that use Tocris products.

Currently there are no citations for TCPOBOP. Do you know of a great paper that uses TCPOBOP from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Nuclear Receptors

Nuclear Receptors Product Listing

A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

  • Androgen Receptors
  • Estrogen Receptors
  • Retinoic Acid Receptors
  • Retinoid X Receptors
  • Vitamin D Receptors

Pathways for TCPOBOP

Protocols

TODO: Add Protocols