NMDA receptor antagonist selective for NR1/NR2A over NR1/NR2B-containing receptors (pIC50 values are 6.8 and <4.3, respectively, in human recombinant NR1/NR2A and NR1/NR2B FLIPR/Ca2+ assays).
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 461.89. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.17 mL||10.83 mL||21.65 mL|
|5 mM||0.43 mL||2.17 mL||4.33 mL|
|10 mM||0.22 mL||1.08 mL||2.17 mL|
|50 mM||0.04 mL||0.22 mL||0.43 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Bettini et al (2010) Identification and characterization of novel NMDA receptor antagonists selective for NR2A- over NR2B-containing receptors. J.Pharm.Exp.Ther. 335 644 PMID: 20810618
Shin et al (2011) Subtype selective NMDA receptor antagonists induce recovery of synapses lost following exposure to HIV-1 Tat. Br.J.Pharmacol. 166 1002 PMID: 22142193
Edman et al (2012) TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist dependent but non-competitive manner. Neuropharmacology 63 441 PMID: 22579927
Hansen et al (2012) Subunit-selective allosteric inhibition of glycine binding to NMDA receptors. J.Neurosci. 32 6197 PMID: 22553026
Gipson et al (2013) Reinstatement of nicotine seeking is mediated by glutamatergic plasticity. Proc.Natl.Acad.Sci.U S A [Epub ahead of print] PMID: 23671067
If you know of a relevant reference for TCN 201, please let us know.
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Keywords: TCN201 NMDA receptor agonist selective NR1/NR2A antagonist NMDA Receptors
7 Citations for TCN 201
Citations are publications that use Tocris products. Selected citations for TCN 201 include:
Chen et al (2016) β-arrestin-2 regulates NMDA receptor function in spinal lamina II neurons and duration of persistent pain. Nature Communications 7 12531 PMID: 27538456
Tian et al (2016) STEP activation by Gαq coupled GPCRs opposes Src regulation of NMDA receptors containing the GluN2A subunit Scientific Reports 6 36684 PMID: 27857196
Gu et al (2015) miR-26a and miR-384-5p are required for LTP maintenance and spine enlargement. Nat Commun 6 6789 PMID: 25858512
Liu et al (2015) The distinct role of NR2B subunit in the enhancement of visual plasticity in adulthood. Mol Brain 8 49 PMID: 26282667
Hu et al (2015) miR-501-3p mediates the activity-dependent regulation of the expression of AMPA receptor subunit GluA1. J Pharmacol Exp Ther 208 949 PMID: 25800054
Izumi and Zorumski (2015) Sensitivity of N-methyl-D-aspartate receptor-mediated excitatory postsynaptic potentials and synaptic plasticity to TCN 201 and TCN 213 in rat hippocampal slices. PeerJ 352 267 PMID: 25413830
Jia et al (2013) Age-dependent regulation of synaptic connections by dopamine D2 receptors. Nat Neurosci 16 1627 PMID: 24121738
Do you know of a great paper that uses TCN 201 from Tocris? If so please let us know.
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