Pricing Availability   Qty
Cat.No. 5179 - TCID | C9H2Cl4O2 | CAS No. 30675-13-9
Description: Selective ubiquitin C-terminal hydrolase-L3 (UCH-L3) inhibitor
Chemical Name: 4,5,6,7-Tetrachloro-1H-Indene-1,3(2H)-dione
Purity: ≥99% (HPLC)

Biological Activity

Selective ubiquitin C-terminal hydrolase-L3 (UCH-L3) inhibitor (IC50 = 0.6 μM). Exhibits >100-fold selectivity for UCH-L3 over UCH-L1. Diminishes glycine transporter GlyT2 ubiquitination in brain stem and spinal cord primary neurons.

Technical Data

M. Wt 283.92
Formula C9H2Cl4O2
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 30675-13-9
PubChem ID 2729042
Smiles O=C(CC2=O)C1=C2C(Cl)=C(Cl)C(Cl)=C1Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 14.2 50

Preparing Stock Solutions

The following data is based on the product molecular weight 283.92. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 7.04 mL 35.22 mL 70.44 mL
2.5 mM 1.41 mL 7.04 mL 14.09 mL
5 mM 0.7 mL 3.52 mL 7.04 mL
25 mM 0.14 mL 0.7 mL 1.41 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.


References are publications that support the biological activity of the product.

Liu et al (2003) Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem.Biol. 10 837 PMID: 14522054

de Juan-Sanz et al (2013) Constitutive endocytosis and turnover of the neuronal glycine transporter GlyT2 is dependent on ubiquitination of a C-terminal lysine cluster. PLoS ONE 8 e58863 PMID: 23484054

If you know of a relevant reference for TCID, please let us know.

View Related Products by Product Action

View all Deubiquitinating Enzyme Inhibitors

Keywords: TCID, TCID supplier, selective, ubiquitin, c-terminal, hydrolase-L3, UCH-L3, UCHL3, inhibitors, inhibits, deubiquitinating, enzymes, DUBs, ubiquitination, Deubiquitinating, Enzymes, 5179, Tocris Bioscience

Citations for TCID

Citations are publications that use Tocris products.

Currently there are no citations for TCID. Do you know of a great paper that uses TCID from Tocris? Please let us know.

Reviews for TCID

There are currently no reviews for this product. Be the first to review TCID and earn rewards!

Have you used TCID?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

New Product Guide

New Product Guide (Fall/Winter 2018/2019)

Our new product guide highlights over 190 new products added to the Tocris Bioscience range during the second half of 2018.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Chemogenetics
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells