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Description: Selective ubiquitin C-terminal hydrolase-L3 (UCH-L3) inhibitor
Chemical Name: 4,5,6,7-Tetrachloro-1H-Indene-1,3(2H)-dione
Purity: ≥99% (HPLC)

Biological Activity for TCID

TCID is a selective ubiquitin C-terminal hydrolase-L3 (UCH-L3) inhibitor (IC50 = 0.6 μM). Exhibits >100-fold selectivity for UCH-L3 over UCH-L1. Diminishes glycine transporter GlyT2 ubiquitination in brain stem and spinal cord primary neurons.

Technical Data for TCID

M. Wt 283.92
Formula C9H2Cl4O2
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 30675-13-9
PubChem ID 2729042
Smiles O=C(CC2=O)C1=C2C(Cl)=C(Cl)C(Cl)=C1Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TCID

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 14.2 50

Preparing Stock Solutions for TCID

The following data is based on the product molecular weight 283.92. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 7.04 mL 35.22 mL 70.44 mL
2.5 mM 1.41 mL 7.04 mL 14.09 mL
5 mM 0.7 mL 3.52 mL 7.04 mL
25 mM 0.14 mL 0.7 mL 1.41 mL

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References for TCID

References are publications that support the biological activity of the product.

Liu et al (2003) Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem.Biol. 10 837 PMID: 14522054

de Juan-Sanz et al (2013) Constitutive endocytosis and turnover of the neuronal glycine transporter GlyT2 is dependent on ubiquitination of a C-terminal lysine cluster. PLoS ONE 8 e58863 PMID: 23484054

If you know of a relevant reference for TCID, please let us know.

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Keywords: TCID, TCID supplier, selective, ubiquitin, c-terminal, hydrolase-L3, UCH-L3, UCHL3, inhibitors, inhibits, deubiquitinating, enzymes, DUBs, ubiquitination, Deubiquitinating, Enzymes, 5179, Tocris Bioscience

Citations for TCID

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