TCID

Pricing Availability Delivery Time Qty
Cat.No. 5179 - TCID | C9H2Cl4O2 | CAS No. 30675-13-9
Description: Selective ubiquitin C-terminal hydrolase-L3 (UCH-L3) inhibitor
Chemical Name: 4,5,6,7-Tetrachloro-1H-Indene-1,3(2H)-dione
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective ubiquitin C-terminal hydrolase-L3 (UCH-L3) inhibitor (IC50 = 0.6 μM). Exhibits >100-fold selectivity for UCH-L3 over UCH-L1. Diminishes glycine transporter GlyT2 ubiquitination in brain stem and spinal cord primary neurons.

Technical Data

M. Wt 283.92
Formula C9H2Cl4O2
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 30675-13-9
PubChem ID 2729042
InChI Key IDLAOWFFKWRNHB-UHFFFAOYSA-N
Smiles O=C(CC2=O)C1=C2C(Cl)=C(Cl)C(Cl)=C1Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 14.2 50

Preparing Stock Solutions

The following data is based on the product molecular weight 283.92. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.52 mL 17.61 mL 35.22 mL
5 mM 0.7 mL 3.52 mL 7.04 mL
10 mM 0.35 mL 1.76 mL 3.52 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

Liu et al (2003) Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem.Biol. 10 837 PMID: 14522054

de Juan-Sanz et al (2013) Constitutive endocytosis and turnover of the neuronal glycine transporter GlyT2 is dependent on ubiquitination of a C-terminal lysine cluster. PLoS ONE 8 e58863 PMID: 23484054


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Keywords: TCID, supplier, selective, ubiquitin, c-terminal, hydrolase-L3, UCH-L3, UCHL3, inhibitors, inhibits, deubiquitinating, enzymes, DUBs, ubiquitination, Deubiquitinating, Enzymes, Tocris Bioscience

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New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

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  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

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