TC-T 6000

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Cat.No. 5100 - TC-T 6000 | C26H48N8O2 | CAS No. 949467-71-4
Description: Potent equilibrative nucleoside transporter 4 (ENT4) inhibitor
Chemical Name: 2,2'-[[4,8-Bis[bis(2-methylpropyl)amino]pyrimido[5,4-d]pyrimidine-2,6-diyl]diimino]bis-ethanol
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent equilibrative nucleoside transporter 4 (ENT4) inhibitor (IC50 = 74.4 nM). Exhibits 20-fold and 80-fold selectivity for ENT4 over ENT2 and ENT1, respectively.

Technical Data

M. Wt 504.71
Formula C26H48N8O2
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 949467-71-4
PubChem ID 16757265
InChI Key KIZLZYHFIWWKIL-UHFFFAOYSA-N
Smiles CC(C)CN(CC(C)C)C2=NC(NCCO)=NC1=C(N(CC(C)C)CC(C)C)N=C(NCCO)N=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.09 20
ethanol 10.09 20

Preparing Stock Solutions

The following data is based on the product molecular weight 504.71. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 9.91 mL 49.53 mL 99.07 mL
1 mM 1.98 mL 9.91 mL 19.81 mL
2 mM 0.99 mL 4.95 mL 9.91 mL
10 mM 0.2 mL 0.99 mL 1.98 mL

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References

References are publications that support the biological activity of the product.

Wang et al (2013) Dipyridamole analogs as pharmacological inhibitors of equilibrative nucleoside transporters. Identification of novel potent and selective inhibitors of the adenosine transporter function of human equilibrative nucleoside transporter 4 (hENT4). Biochem.Pharmacol. 86 1531 PMID: 24021350


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Citations for TC-T 6000

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Literature in this Area

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