TC-T 6000

Pricing Availability Delivery Time Qty
Cat.No. 5100 - TC-T 6000 | C26H48N8O2 | CAS No. 949467-71-4
Description: Potent equilibrative nucleoside transporter 4 (ENT4) inhibitor
Chemical Name: 2,2'-[[4,8-Bis[bis(2-methylpropyl)amino]pyrimido[5,4-d]pyrimidine-2,6-diyl]diimino]bis-ethanol
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent equilibrative nucleoside transporter 4 (ENT4) inhibitor (IC50 = 74.4 nM). Exhibits 20-fold and 80-fold selectivity for ENT4 over ENT2 and ENT1, respectively.

Technical Data

M. Wt 504.71
Formula C26H48N8O2
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 949467-71-4
PubChem ID 16757265
InChI Key KIZLZYHFIWWKIL-UHFFFAOYSA-N
Smiles CC(C)CN(CC(C)C)C2=NC(NCCO)=NC1=C(N(CC(C)C)CC(C)C)N=C(NCCO)N=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.09 20
ethanol 10.09 20

Preparing Stock Solutions

The following data is based on the product molecular weight 504.71. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.98 mL 9.91 mL 19.81 mL
5 mM 0.4 mL 1.98 mL 3.96 mL
10 mM 0.2 mL 0.99 mL 1.98 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Wang et al (2013) Dipyridamole analogs as pharmacological inhibitors of equilibrative nucleoside transporters. Identification of novel potent and selective inhibitors of the adenosine transporter function of human equilibrative nucleoside transporter 4 (hENT4). Biochem.Pharmacol. 86 1531 PMID: 24021350


If you know of a relevant reference for TC-T 6000, please let us know.

View Related Products by Product Action

View all Nucleoside Transporter Inhibitors

Keywords: potent selective ENT4 inhibitors inhibits equilibrative nucleoside transporter 4 Nucleoside Transporters

Citations for TC-T 6000

Citations are publications that use Tocris products.

Currently there are no citations for TC-T 6000. Do you know of a great paper that uses TC-T 6000 from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Pathways for TC-T 6000

Protocols

TODO: Add Protocols