TC-SP 14

Pricing Availability Delivery Time Qty
Cat.No. 4363 - TC-SP 14 | C25H20F2N2O2S | CAS No. 1257093-40-5
Description: Potent S1P1 receptor agonist
Chemical Name: 1-[[3-Fluoro-4-[5-[(2-fluorophenyl)methyl]-2-benzothiazolyl]phenyl]methyl]-3-azetidinecarboxylic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent and selective S1P1 agonist (EC50 values are 0.042 and 3.47 μM for human S1P1 and S1P3 respectively). Attenuates immune response to antigen challenge and reduces circulating blood lymphocyte counts in a rodent model of delayed-type hypersensitivity. Orally bioavailable.

Compound Libraries

TC-SP 14 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 450.5
Formula C25H20F2N2O2S
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1257093-40-5
PubChem ID 51346934
InChI Key GVXGVDIXINMAAL-UHFFFAOYSA-N
Smiles FC(C=C(CN4CC(C(O)=O)C4)C=C3)=C3C2=NC1=CC(CC5=CC=CC=C5F)=CC=C1S2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 22.52 50mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 450.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.22 mL 11.1 mL 22.2 mL
5 mM 0.44 mL 2.22 mL 4.44 mL
10 mM 0.22 mL 1.11 mL 2.22 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Lanman et al (2011) Discovery of a potent, S1P3-sparing benzothiazole agonist of sphingosine-1-phosphate receptor 1 (S1P1). ACS Med.Chem.Lett. 2 102 PMID:


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View all Sphingosine-1-Phosphate Receptor Agonists

Keywords: TCSP14 Potent sphingosine 1 phosphate 1 receptor S1P1 agonist delayed type hypersensitivity immune response orally bioavailable Sphingosine-1-phosphate Receptors

Citations for TC-SP 14

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Pathways for TC-SP 14

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