TC-SP 14

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Cat.No. 4363 - TC-SP 14 | C25H20F2N2O2S | CAS No. 1257093-40-5
Description: Potent S1P1 receptor agonist
Chemical Name: 1-[[3-Fluoro-4-[5-[(2-fluorophenyl)methyl]-2-benzothiazolyl]phenyl]methyl]-3-azetidinecarboxylic acid
Purity: ≥98% (HPLC)
Literature (3)

Biological Activity for TC-SP 14

TC-SP 14 is a potent and selective S1P1 agonist (EC50 values are 0.042 and 3.47 μM for human S1P1 and S1P3 respectively). Attenuates immune response to antigen challenge and reduces circulating blood lymphocyte counts in a rodent model of delayed-type hypersensitivity. Orally bioavailable.

Technical Data for TC-SP 14

M. Wt 450.5
Formula C25H20F2N2O2S
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1257093-40-5
PubChem ID 51346934
Smiles FC(C=C(CN4CC(C(O)=O)C4)C=C3)=C3C2=NC1=CC(CC5=CC=CC=C5F)=CC=C1S2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TC-SP 14

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 22.52 50 with gentle warming

Preparing Stock Solutions for TC-SP 14

The following data is based on the product molecular weight 450.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.44 mL 22.2 mL 44.4 mL
2.5 mM 0.89 mL 4.44 mL 8.88 mL
5 mM 0.44 mL 2.22 mL 4.44 mL
25 mM 0.09 mL 0.44 mL 0.89 mL

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Product Datasheets for TC-SP 14

Certificate of Analysis / Product Datasheet
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References for TC-SP 14

References are publications that support the biological activity of the product.

Lanman et al (2011) Discovery of a potent, S1P3-sparing benzothiazole agonist of sphingosine-1-phosphate receptor 1 (S1P1). ACS Med.Chem.Lett. 2 102

If you know of a relevant reference for TC-SP 14, please let us know.

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Keywords: TC-SP 14, TC-SP 14 supplier, TCSP14, Potent, sphingosine, 1, phosphate, receptor, S1P1, agonist, delayed, type, hypersensitivity, immune, response, orally, bioavailable, Sphingosine-1-phosphate, Receptors, 4363, Tocris Bioscience

Citations for TC-SP 14

Citations are publications that use Tocris products.

Currently there are no citations for TC-SP 14. Do you know of a great paper that uses TC-SP 14 from Tocris? Please let us know.

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