TC-S 7010

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Description: Potent and selective Aurora kinase A inhibitor
Chemical Name: N-(2-Chlorophenyl)-4-[[2-[[4-[2-(4-ethyl-1-piperazinyl)-2-oxoethyl]phenyl]amino]-5-fluoro-4-pyrimidinyl]amino]-benzamide
Purity: ≥99% (HPLC)
Citations (1)
Literature (2)

Biological Activity for TC-S 7010

TC-S 7010 is a potent and selective inhibitor of Aurora kinase A (IC50 = 3.4 nM); exhibits 1000-fold selectivity for Aurora kinase A over Aurora kinase B. Displays antiproliferative activity in HCT116 and HT29 cells (IC50 values are 0.19 and 2.9 μM respectively).

Technical Data for TC-S 7010

M. Wt 588.07
Formula C31H31ClFN7O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1158838-45-9
PubChem ID 44139710
Smiles O=C(NC3=CC=CC=C3Cl)C(C=C2)=CC=C2NC1=C(F)C=NC(NC4=CC=C(CC(N5CCN(CC)CC5)=O)C=C4)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TC-S 7010

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 58.81 100

Preparing Stock Solutions for TC-S 7010

The following data is based on the product molecular weight 588.07. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.7 mL 8.5 mL 17 mL
5 mM 0.34 mL 1.7 mL 3.4 mL
10 mM 0.17 mL 0.85 mL 1.7 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

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References for TC-S 7010

References are publications that support the biological activity of the product.

Aliagas-Martin et al (2009) A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B. J.Med.Chem. 52 3300 PMID: 19402633

Yuan et al (2012) Overcoming CML acquired resistance by specific inhibition of Aurora A kinse in the KCL-22 cell model. Carcinogenesis 33 285 PMID: 22116466

If you know of a relevant reference for TC-S 7010, please let us know.

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Keywords: TC-S 7010, TC-S 7010 supplier, TC-S7010, Aurora, kinase, A, potent, selective, inhibitors, inhibits, antiproliferative, Kinases, 5286, Tocris Bioscience

1 Citation for TC-S 7010

Citations are publications that use Tocris products. Selected citations for TC-S 7010 include:

Alexandre et al (2020) KIF14 controls ciliogenesis via regulation of Aurora A and is important for Hedgehog signaling. J Cell Biol 219 PMID: 32348467

Do you know of a great paper that uses TC-S 7010 from Tocris? Please let us know.

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Literature in this Area

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