TC-S 7009

Pricing Availability Delivery Time Qty
Cat.No. 5243 - TC-S 7009 | C12H6ClFN4O3 | CAS No. 1422955-31-4
Description: High affinity and selective HIF-2α inhibitor
Chemical Name: N-(3-Chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

High affinity and selective HIF-2α inhibitor (Kd = 81 nM). Binds to the HIF-2α PAS-B domain; disrupts HIF-2α-ARNT heterodimerization. Exhibits >60-fold selectivity for HIF-2α over HIF-1α. Decreases HIF-2α DNA-binding and attenuates expression of HIF-2α target genes in vitro.

Compound Libraries

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Technical Data

M. Wt 308.65
Formula C12H6ClFN4O3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 1422955-31-4
PubChem ID 70697712
InChI Key CDQUJZKBRAFWNG-UHFFFAOYSA-N
Smiles ClC1=CC(F)=CC(NC3=C([N+]([O-])=O)C2=NON=C2C=C3)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.86 100

Preparing Stock Solutions

The following data is based on the product molecular weight 308.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.24 mL 16.2 mL 32.4 mL
5 mM 0.65 mL 3.24 mL 6.48 mL
10 mM 0.32 mL 1.62 mL 3.24 mL
50 mM 0.06 mL 0.32 mL 0.65 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Scheuermann et al (2013) Allosteric inhibition of hypoxia inducible factor-2 with small molecules. Nat.Chem.Biol. 9 271 PMID: 23434853

Rogers et al (2013) Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor. J.Med.Chem. 56 1739 PMID: 23363003


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View all Hypoxia Inducible Factor Inhibitors

Keywords: TC-S7009 high affinity inhibits inhibitors HIF2α HIF2a HIF2alpha PASB hypoxia-inducible factors HIF

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Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

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Angiogenesis in Cancer

Angiogenesis in Cancer Poster

Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

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