TC-O 9311

Pricing Availability   Qty
Description: Potent and selective GPR139 agonist
Chemical Name: 3,5-Dimethoxybenzoic acid 2-[(1-naphthalenylamino)carbonyl]hydrazide
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity for TC-O 9311

TC-O 9311 is a potent GPR139 agonist (EC50 = 39 nM in CHO-K1 cells expressing human GPR139). Displays no activity against a range of 90 diverse targets.

Compound Libraries for TC-O 9311

TC-O 9311 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for TC-O 9311

M. Wt 365.38
Formula C20H19N3O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 444932-31-4
PubChem ID 3376937
Smiles O=C(NNC(NC2=CC=CC3=C2C=CC=C3)=O)C1=CC(OC)=CC(OC)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TC-O 9311

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 18.27 50

Preparing Stock Solutions for TC-O 9311

The following data is based on the product molecular weight 365.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.47 mL 27.37 mL 54.74 mL
2.5 mM 1.09 mL 5.47 mL 10.95 mL
5 mM 0.55 mL 2.74 mL 5.47 mL
25 mM 0.11 mL 0.55 mL 1.09 mL

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References for TC-O 9311

References are publications that support the biological activity of the product.

Shi et al (2011) Discovery and SAR of a series of agonists at orphan G protein-coupled receptor 139. ACS Med.Chem.Lett. 2 303 PMID: 24900311

If you know of a relevant reference for TC-O 9311, please let us know.

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1 Citation for TC-O 9311

Citations are publications that use Tocris products. Selected citations for TC-O 9311 include:

Nepomuceno et al (2018) Re-evaluation of Adrenocorticotropic Hormone and Melanocyte Stimulating Hormone Activation of GPR139 in Vitro. Front Pharmacol 9 157 PMID: 29599718

Do you know of a great paper that uses TC-O 9311 from Tocris? Please let us know.

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