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Submit ReviewTC-G 1006
Discontinued Product
4747 has been discontinued.
View all Sphingosine-1-Phosphate Receptors products.
Description: Potent and selective sphingosine-1-phosphate receptor 1 (S1P1) agonist
Chemical Name: 4-Methoxy-N-[[[2-trifluoromethyl)[1,1'-biphenyl]-4-yl]amino]carbonyl]-3-pyridinecarboxamide
Purity: ≥98% (HPLC)
Biological Activity for TC-G 1006
TC-G 1006 is a potent and selective sphingosine-1-phosphate receptor 1 (S1P1) agonist (EC50 = 35 nM), displays >100-fold selectivity against receptor subtypes S1P2-5. Induces a dose-dependent reduction in circulating blood lymphocyte counts in rodent models. Orally bioavailable.
Technical Data for TC-G 1006
| M. Wt | 415.37 |
| Formula | C21H16F3N3O3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1324003-64-6 |
| PubChem ID | 54764919 |
| InChI Key | MLDQTQOMWDNTNN-UHFFFAOYSA-N |
| Smiles | O=C(NC(C2=C(OC)C=CN=C2)=O)NC1=CC=C(C3=CC=CC=C3)C(C(F)(F)F)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for TC-G 1006
References for TC-G 1006
References are publications that support the biological activity of the product.
Pennington et al (2011) 4-Methoxy-N-[2-(trifluoromethyl)biphenyl-4-ylcarbamoyl]nicotinamide: A Potent and Selective Agonist of S1P1. ACS Med.Chem.Lett. 2 752 PMID: 24900263
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Keywords: TC-G 1006, TC-G 1006 supplier, TC-G1006, Sphingosine-1-phosphate, receptor, 1, agonists, Receptors, 4747, Tocris Bioscience
Citations for TC-G 1006
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