TC-G 1006

Pricing Availability   Qty
Cat.No. 4747 - TC-G 1006 | C21H16F3N3O3 | CAS No. 1324003-64-6
Description: Potent and selective sphingosine-1-phosphate receptor 1 (S1P1) agonist
Chemical Name: 4-Methoxy-N-[[[2-trifluoromethyl)[1,1'-biphenyl]-4-yl]amino]carbonyl]-3-pyridinecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and selective sphingosine-1-phosphate receptor 1 (S1P1) agonist (EC50 = 35 nM), displays >100-fold selectivity against receptor subtypes S1P2-5. Induces a dose-dependent reduction in circulating blood lymphocyte counts in rodent models. Orally bioavailable.

Compound Libraries

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Technical Data

M. Wt 415.37
Formula C21H16F3N3O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1324003-64-6
PubChem ID 54764919
InChI Key MLDQTQOMWDNTNN-UHFFFAOYSA-N
Smiles O=C(NC(C2=C(OC)C=CN=C2)=O)NC1=CC=C(C3=CC=CC=C3)C(C(F)(F)F)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 100 mM in DMSO

References

References are publications that support the biological activity of the product.

Pennington et al (2011) 4-Methoxy-N-[2-(trifluoromethyl)biphenyl-4-ylcarbamoyl]nicotinamide: A Potent and Selective Agonist of S1P1. ACS Med.Chem.Lett. 2 752 PMID: 24900263


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Keywords: TC-G 1006, TC-G 1006 supplier, TC-G1006, Sphingosine-1-phosphate, receptor, 1, agonists, Receptors, 4747, Tocris Bioscience

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