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Submit ReviewTC-G 1006 is a potent and selective sphingosine-1-phosphate receptor 1 (S1P1) agonist (EC50 = 35 nM), displays >100-fold selectivity against receptor subtypes S1P2-5. Induces a dose-dependent reduction in circulating blood lymphocyte counts in rodent models. Orally bioavailable.
M. Wt | 415.37 |
Formula | C21H16F3N3O3 |
Storage | Store at +4°C |
Purity | ≥98% (HPLC) |
CAS Number | 1324003-64-6 |
PubChem ID | 54764919 |
InChI Key | MLDQTQOMWDNTNN-UHFFFAOYSA-N |
Smiles | O=C(NC(C2=C(OC)C=CN=C2)=O)NC1=CC=C(C3=CC=CC=C3)C(C(F)(F)F)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 100 |
The following data is based on the product molecular weight 415.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 2.41 mL | 12.04 mL | 24.07 mL |
5 mM | 0.48 mL | 2.41 mL | 4.81 mL |
10 mM | 0.24 mL | 1.2 mL | 2.41 mL |
50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
References are publications that support the biological activity of the product.
Pennington et al (2011) 4-Methoxy-N-[2-(trifluoromethyl)biphenyl-4-ylcarbamoyl]nicotinamide: A Potent and Selective Agonist of S1P1. ACS Med.Chem.Lett. 2 752 PMID: 24900263
If you know of a relevant reference for TC-G 1006, please let us know.
Keywords: TC-G 1006, TC-G 1006 supplier, TC-G1006, Sphingosine-1-phosphate, receptor, 1, agonists, Receptors, 4747, Tocris Bioscience
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