TC-G 1006

Pricing Availability Delivery Time Qty
Cat.No. 4747 - TC-G 1006 | C21H16F3N3O3 | CAS No. 1324003-64-6
Description: Potent and selective sphingosine-1-phosphate receptor 1 (S1P1) agonist
Chemical Name: 4-Methoxy-N-[[[2-trifluoromethyl)[1,1'-biphenyl]-4-yl]amino]carbonyl]-3-pyridinecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and selective sphingosine-1-phosphate receptor 1 (S1P1) agonist (EC50 = 35 nM), displays >100-fold selectivity against receptor subtypes S1P2-5. Induces a dose-dependent reduction in circulating blood lymphocyte counts in rodent models. Orally bioavailable.

Compound Libraries

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Technical Data

M. Wt 415.37
Formula C21H16F3N3O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1324003-64-6
PubChem ID 54764919
InChI Key MLDQTQOMWDNTNN-UHFFFAOYSA-N
Smiles O=C(NC(C2=C(OC)C=CN=C2)=O)NC1=CC=C(C3=CC=CC=C3)C(C(F)(F)F)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in DMSO

Preparing Stock Solutions

The following data is based on the product molecular weight 415.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.41 mL 12.04 mL 24.07 mL
5 mM 0.48 mL 2.41 mL 4.81 mL
10 mM 0.24 mL 1.2 mL 2.41 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Pennington et al (2011) 4-Methoxy-N-[2-(trifluoromethyl)biphenyl-4-ylcarbamoyl]nicotinamide: A Potent and Selective Agonist of S1P1. ACS Med.Chem.Lett. 2 752 PMID: 24900263


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Keywords: TC-G 1006, supplier, TC-G1006, Sphingosine-1-phosphate, receptor, 1, agonists, Sphingosine-1-phosphate, Receptors, Sphingosine-1-phosphate, Receptors, Tocris Bioscience

Citations for TC-G 1006

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Literature in this Area

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