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TC-G 1006

Cat. No. 4747 Submit a Review Datasheet / COA / SDS
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Cat.No. 4747 - TC-G 1006 | C21H16F3N3O3 | CAS No. 1324003-64-6
Description: Potent and selective sphingosine-1-phosphate receptor 1 (S1P1) agonist
Chemical Name: 4-Methoxy-N-[[[2-trifluoromethyl)[1,1'-biphenyl]-4-yl]amino]carbonyl]-3-pyridinecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent and selective sphingosine-1-phosphate receptor 1 (S1P1) agonist (EC50 = 35 nM), displays >100-fold selectivity against receptor subtypes S1P2-5. Induces a dose-dependent reduction in circulating blood lymphocyte counts in rodent models. Orally bioavailable.

Technical Data

M. Wt 415.37
Formula C21H16F3N3O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1324003-64-6
PubChem ID 54764919
InChI Key MLDQTQOMWDNTNN-UHFFFAOYSA-N
Smiles O=C(NC(C2=C(OC)C=CN=C2)=O)NC1=CC=C(C3=CC=CC=C3)C(C(F)(F)F)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 100

Preparing Stock Solutions

The following data is based on the product molecular weight 415.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.41 mL 12.04 mL 24.07 mL
5 mM 0.48 mL 2.41 mL 4.81 mL
10 mM 0.24 mL 1.2 mL 2.41 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

Molarity Calculator

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References

References are publications that support the biological activity of the product.

Pennington et al (2011) 4-Methoxy-N-[2-(trifluoromethyl)biphenyl-4-ylcarbamoyl]nicotinamide: A Potent and Selective Agonist of S1P1. ACS Med.Chem.Lett. 2 752 PMID: 24900263

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Keywords: TC-G 1006, TC-G 1006 supplier, TC-G1006, Sphingosine-1-phosphate, receptor, 1, agonists, Receptors, 4747, Tocris Bioscience

Citations for TC-G 1006

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