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Biological Activity for TC-G 1005
TC-G 1005 is a potent and selective GPBA agonist (EC50 = 0.72 nM for hTGR5). Selective for TGR5 over FXR (farnesoid X receptor). Increases plasma GLP-1 levels and reduces blood glucose in mice. Orally available.
Compound Libraries for TC-G 1005
Technical Data for TC-G 1005
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TC-G 1005
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for TC-G 1005
The following data is based on the product molecular weight 399.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.5 mL||12.52 mL||25.03 mL|
|5 mM||0.5 mL||2.5 mL||5.01 mL|
|10 mM||0.25 mL||1.25 mL||2.5 mL|
|50 mM||0.05 mL||0.25 mL||0.5 mL|
References for TC-G 1005
References are publications that support the biological activity of the product.
Duan et al (2012) Design, synthesis, and antidiabetic activity of 4-phenoxynicotinamide and 4-phenoxypyrimidine-5-carboxamide derivatives as potent and orally efficacious TGR5 agonists. J.Med.Chem. 55 10475 PMID: 23148522
If you know of a relevant reference for TC-G 1005, please let us know.
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Keywords: TC-G 1005, TC-G 1005 supplier, TC-G1005, TGR5, agonists, agonism, GLP-1, GPBA, glucose, bile, acid, receptors, Receptors, 5129, Tocris Bioscience
Citations for TC-G 1005
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Literature in this Area
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