TC-E 5008

Discontinued Product

TC-E 5008 (Cat. No. 5244) has been withdrawn from sale for commercial reasons.
Description: Selective mutant isocitrate dehydrogenase 1 (mIDH1) inhibitor; phenotypically lethal
Alternative Names: SYC 435
Chemical Name: 1-Hydroxy-4-methyl-6-(phenylmethyl)-2-(1H)pyridinone
Literature (4)

Biological Activity for TC-E 5008

TC-E 5008 is a selective mutant isocitrate dehydrogenase 1 (mIDH1) inhibitor (Ki = 120-190 nM). Displays >60-fold selectivity for mIDH1 (found in ~75% of gliomas) over wild type IDH1. Also inhibits D-2-hydroxyglutaric acid in cells expressing mIDH1 (EC50 = 2.4 μM). Does not display cytotoxicity towards non-cancerous human cells. Phenotypically lethal.

Technical Data for TC-E 5008

M. Wt 215.25
Formula C13H13NO2
Storage Store at +4°C
CAS Number 50405-58-8
PubChem ID 13590964
Smiles O=C1C=C(C)C=C(CC2=CC=CC=C2)N1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for TC-E 5008

References are publications that support the biological activity of the product.

Zheng et al (2013) Crystallographic investigation and selective inhibition of mutant isocitrate dehydrogenase. ACS Med.Chem.Lett. 4 542 PMID: 23795241

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Citations for TC-E 5008

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Currently there are no citations for TC-E 5008.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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