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Submit ReviewTC-E 5005 is a potent and selective PDE10A inhibitor (IC50 values are 7.28, 239, 779, 919, 3100 and 3700 nM at PDE10A, 2A, 11A, 5A, 7B and 3A respectively and >5000 nM at PDE1B, 4A, 6, 8A and 9A). Reverses MK 801-induced hyperactivity in vivo.
M. Wt | 270.33 |
Formula | C15H18N4O |
Storage | Store at +4°C |
Purity | ≥99% (HPLC) |
CAS Number | 959705-64-7 |
PubChem ID | 24802717 |
InChI Key | YNADXFWEXJTQSZ-UHFFFAOYSA-N |
Smiles | CC2=NC1=CC=C(OC)N=C1N3C2=C(C)N=C3CCC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Hofgen et al (2010) Discovery of imidazo[1,5-a]pyrido[3,2-e]pyrazines as a new class of phosphodiesterase 10A inhibitiors. J.Med.Chem. 53 4399 PMID: 20450197
Keywords: TC-E 5005, TC-E 5005 supplier, TC-E5005, PDE10A, inhibitors, inhibits, phosphodiesterase, 10A, potent, selective, Phosphodiesterases, 4572, Tocris Bioscience
Citations are publications that use Tocris products.
Currently there are no citations for TC-E 5005.
Average Rating: 4 (Based on 1 Review.)
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Dosed product into cell culture media to final concentration of 10uM and at various time points up to 72h and isolated RNA from cells for downstream qPCR analysis to review effect of PDE inhibition on cell line phenotype.
Gentle warming of solution while resuspending in 45C water bath was very helpful in the process.