TC-E 5005

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Cat.No. 4572 - TC-E 5005 | CAS No. 959705-64-7
Description: Potent and selective PDE10A inhibitor
Chemical Name: 2-Methoxy-6,7-dimethyl-9-propyl-imidazo[1,5-a]pyrido[3,2-e]pyrazine
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews (1)
Literature

Biological Activity

Potent and selective PDE10A inhibitor (IC50 values are 7.28, 239, 779, 919, 3100 and 3700 nM at PDE10A, 2A, 11A, 5A, 7B and 3A respectively and >5000 nM at PDE1B, 4A, 6, 8A and 9A). Reverses MK 801-induced hyperactivity in vivo.

Technical Data

M. Wt 270.33
Formula C15H18N4O
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 959705-64-7
PubChem ID 24802717
InChI Key YNADXFWEXJTQSZ-UHFFFAOYSA-N
Smiles CC2=NC1=CC=C(OC)N=C1N3C2=C(C)N=C3CCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 27.03 100
ethanol 27.03 100

Preparing Stock Solutions

The following data is based on the product molecular weight 270.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.7 mL 18.5 mL 36.99 mL
5 mM 0.74 mL 3.7 mL 7.4 mL
10 mM 0.37 mL 1.85 mL 3.7 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

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References

References are publications that support the biological activity of the product.

Hofgen et al (2010) Discovery of imidazo[1,5-a]pyrido[3,2-e]pyrazines as a new class of phosphodiesterase 10A inhibitiors. J.Med.Chem. 53 4399 PMID: 20450197


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Keywords: TC-E 5005, TC-E 5005 supplier, TC-E5005, PDE10A, inhibitors, inhibits, phosphodiesterase, 10A, potent, selective, Phosphodiesterases, 4572, Tocris Bioscience

Citations for TC-E 5005

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PDE inhibition assay in tissue culture
By Anonymous on 01/04/2018
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: Hela x fibroblast hybrid

Dosed product into cell culture media to final concentration of 10uM and at various time points up to 72h and isolated RNA from cells for downstream qPCR analysis to review effect of PDE inhibition on cell line phenotype.

Gentle warming of solution while resuspending in 45C water bath was very helpful in the process.


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