TC-A 2317 hydrochloride

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Description: Potent, selective Aurora kinase A inhibitor
Chemical Name: 2-[(5-Hydroxy-1,5-dimethylhexyl)amino]-4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]-3-pyridinecarbonitrile hydrochloride
Purity: ≥98% (HPLC)
Citations (3)
Literature (2)

Biological Activity for TC-A 2317 hydrochloride

TC-A 2317 hydrochloride is a potent Aurora kinase A inhibitor (Ki = 1.2 nM compared to 101 nM for inhibition of Aurora kinase B). Selective over 60 other kinases (IC50 values > 1000 nM). Exhibits good cell permeability and antitumor activity.

Technical Data for TC-A 2317 hydrochloride

M. Wt 392.93
Formula C19H28N6O.HCl
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1245907-03-2
PubChem ID 46911725
Smiles CC1=CC(NC2=NNC(C)=C2)=NC(NC(C)CCCC(C)(C)O)=C1C#N.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TC-A 2317 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 39.29 100
ethanol 19.65 50

Preparing Stock Solutions for TC-A 2317 hydrochloride

The following data is based on the product molecular weight 392.93. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.54 mL 12.72 mL 25.45 mL
5 mM 0.51 mL 2.54 mL 5.09 mL
10 mM 0.25 mL 1.27 mL 2.54 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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Product Datasheets for TC-A 2317 hydrochloride

References for TC-A 2317 hydrochloride

References are publications that support the biological activity of the product.

Ando et al (2010) 3-Cyano-6-(-5-methyl-3-pyrazoloamino)pyridines: Selective Aurora A kinase inhibitors. Bioorg.Med.Chem.Lett. 20 4709 PMID: 20573509

If you know of a relevant reference for TC-A 2317 hydrochloride, please let us know.

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Keywords: TC-A 2317 hydrochloride, TC-A 2317 hydrochloride supplier, inhibits, aurora, kinase, a, inhibitors, antitumor, Aurora, A, Kinases, 4066, Tocris Bioscience

3 Citations for TC-A 2317 hydrochloride

Citations are publications that use Tocris products. Selected citations for TC-A 2317 hydrochloride include:

Lucas et al (2018) Kinase-controlled phase transition of membraneless organelles in mitosis. Nature 559 211-216 PMID: 29973724

Wang et al (2019) EGFR-Aurka signaling rescues polarity and regeneration defects in dystrophin-deficient muscle stem cells by increasing asymmetric divisions. Cell Stem Cell 24 419 PMID: 30713094

Min et al (2016) The Aurora kinase A inhibitor TC-A2317 disrupts mitotic progression and inhibits cancer cell proliferation. Oncotarget 7 84718 PMID: 27713168

Do you know of a great paper that uses TC-A 2317 hydrochloride from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

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Cell Cycle & DNA Damage Repair Poster

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.